Scientists find key to growth of bad bacteria in inflamed gut

[nogutsnoglory]

This is an interesting article and could lead to the development of new drugs for IBD.

"The UC Davis team’s research indicates that targeting the molecular pathways that generate nitric oxide and nitrate, as well as other molecules that feed harmful gut bacteria, could calm down and normalize the intestinal environment in IBD, Baumler noted. They are already doing research with one candidate drug that could halt the multiple pathways by which harmful bacteria thrive in IBD.

“The idea would be to inhibit all pathways that produce molecules that can be used by bacteria such as E. coli for respiration and growth,” Baumler said. “Essentially you could then smother the bacteria.”

http://scienceblog.com/59614/scientists-find-key-to-growth-of-bad-bacteria-in-inflamed-gut/

 

[Trysha]

Thank you for posting this interesting information.
These researchers have a monumental task in separating bad from good bacteria.
There are a number of E.coli strains that produce a destructive powerful enterotoxin., and it will be interesting to see how they approach this aspect of toxin producers.
There are other toxigenic bacteria also.
The intestinal tract possesses quite a bacterial ecosystem the balance of which can be
upset by infections, antibiotics and also the way we eat to name a few items..
A huge area for study.
Trysha

 

[mnsun]

Nitrates convert into nitrites when digesting foods like lunch meats, bacon, preserved meats as well as leafy vegetables that have been highly fertilized like spinach, lettuce, cabbage and maybe even root veges. Not sure how much safer organics are in this respect, but I like to think so. It is said that cooking such meats creates liposomal nitrites which may be even more harmful. I haven't researched this enough, but it makes sense.

Some people say taking vitamin C or orange juice, etc, may prevent the conversion of nitrates into nitrites upon digestion. Not sure on the science on this.

 

[mf15]

Adding this info here sine there are two threads on this.
Old Mike
Ways to inhibit iNOS. Will add more when I find them.Looks like a lot of stuff.



Old Mike

First what is it.

http://en.wikipedia.org/wiki/Nitric_oxide_synthase

melatonin

http://bloodjournal.hematologylibrary.org/content/108/2/518.full.pdf

andrographolide

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571992/

CLA

http://www.ncbi.nlm.nih.gov/pubmed/12468265

here is an interesting long thread on a body building forum.

http://www.mindandmuscle.net/forum/1903-nitric-oxide

rosemary

http://pubs.acs.org/doi/abs/10.1021/bk-2003-0859.ch004

B6

http://www.ncbi.nlm.nih.gov/pubmed/12026192



evoo-olive leaf extract seems to contain high amounts of oleuropein which is hydrolyzed

into hydroxytyrosol in the digestive system,as far as I can tell.

http://www.ncbi.nlm.nih.gov/pubmed/21874330

http://en.wikipedia.org/wiki/Hydroxytyrosol