Starting a high CBD regimen

[FullM3lt]

Hey all :cool2:

Some of you may remember me from last year when I was posting more frequently. I was using a strain of cannabis with moderately high levels of CBD (1-2%) and high levels of THC (10%-25%) to manage my ulcerative colitis (Pancolitis). 1-2% on the CBD may seem low, but the average I've seen at the labs in my area is probably around .3%. This regimen has worked well for me, and I have been pretty much asymptomatic for over a year. That being said, I still believe that things could be improved.

I really believe in CBD and its healing properties. There is a ton of scientific and anecdotal information out there supporting CBD and its broad range of medicinal benefits. I believe that strains with a 2:1 ratio of CBD to THC will offer IBD sufferers the greatest benefits. THC may get you "high" but it also has medicinal benefits...the synergy between all of the cannabinoids and terpenes is important IMO.

Here is a quick link and a few excerpts for anybody interested

The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis

Conclusions and implications:

In this model of colitis, THC and CBD not only reduced inflammation but also lowered the occurrence of functional disturbances. Moreover the combination of CBD and THC could be beneficial therapeutically, via additive or potentiating effects.

Key results:

Sulphasalazine, THC and CBD proved beneficial in this model of colitis with the dose–response relationship for the phytocannabinoids showing a bell-shaped pattern on the majority of parameters (optimal THC and CBD dose, 10 mg·kg−1). THC was the most effective drug. The effects of these phytocannabinoids were additive, and CBD increased some effects of an ineffective THC dose to the level of an effective one. THC alone and in combination with CBD protected cholinergic nerves whereas sulphasalazine did not.

Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.


**Source: National Center for Biotechnology Information**


I just recently came into contact with a medical cannabis collective that has a large selection of tested high CBD medication. Today, I picked up two different phenotypes of a strain called Harlequin, and a high CBD pheno of DJ Short's Blueberry.

Harlequin Pheno 1 is: 7.12% CBD 3.81% THC .16% CBG

Harlequin Pheno 2 is: 11.02% THC 5.47% .58% CBG

Blueberry CBD is: 5.25% CBD 2.05% THC .84% CBG

All have been tested at a lab with a gas chromatograph. They also test for mold/mildew and "foreign objects." Everything is 100% clean.

This will be my first experience with high levels of CBD. I picked up enough to last me about 2 weeks. I will document any changes I notice in my bowels, mood, pain levels, etc. My primary method of consumption will be vaporization. Smoke is bad m'kay! If there are no noticeable effects after two weeks, I will try ingesting some decarboxylated high CBD oil.

This is sort of a diary for myself and others that are interested in reading about CBD and IBD. I will report back in a day or two.

 

[FrancisK7]

I got a strain with 10% CBD content and 10% THC that is curing right now.

Im really excited about trying it, never had CBD rich strains before.

My new ingestion preference is via an alcohol based tincture nowadays.

Let us know how it goes.

BTW its not anecdotal anymore, the ability of CBD to modulate and potentiate the effectiveness of THC is irrefutably demonstrated in the literature.

 

[F.u.Crohns]

I got a strain with 10% CBD content and 10% THC that is curing right now.

Im really excited about trying it, never had CBD rich strains before.

My new ingestion preference is via an alcohol based tincture nowadays.

Let us know how it goes.

BTW its not anecdotal anymore, the ability of CBD to modulate and potentiate the effectiveness of THC is irrefutably demonstrated in the literature.

FrancisK,

Why not turn your high cbd herb into oil format instead of tincture. Isn't the oil format more concentrated then the tincture?

 

[FrancisK7]

Actually, a tincture is more potent than an oil based delivery system by weight as alcohol's bioavailability is higher than oil's. I think Rick Simpson used oil because it's cheaper, much easier to get and the transfer is easier as well. You need 94% proof alcohol for tinctures (Everclear) and in Canada a 40 oz bottle costs north of 60$. Oil is a fraction of that price.

A solvent extraction method takes more step (it takes me 72 hours) but it removes ALL the nasty cannabis taste you find in edibles. You can either administer the tincture under your tongue for very quick action, or transfer it back into any edibles, but without the nasty after taste.

Once I discovered the method I never looked back. If you want I can make a detailed photo tutorial and post it here.

 

[F.u.Crohns]

Actually, a tincture is more potent than an oil based delivery system by weight as alcohol's bioavailability is higher than oil's. I think Rick Simpson used oil because it's cheaper, much easier to get and the transfer is easier as well. You need 94% proof alcohol for tinctures (Everclear) and in Canada a 40 oz bottle costs north of 60$. Oil is a fraction of that price.

A solvent extraction method takes more step (it takes me 72 hours) but it removes ALL the nasty cannabis taste you find in edibles. You can either administer the tincture under your tongue for very quick action, or transfer it back into any edibles, but without the nasty after taste.

Once I discovered the method I never looked back. If you want I can make a detailed photo tutorial and post it here.

Yes that be awesome. I try some cbd tincture didn't notice any medication at all unless taking a large amount. But maybe there a process for more potent tincture.

 

[F.u.Crohns]

FrancisK,

Please make tutorial for us, i'm kinda of curious on this method. If you like make a video and post it on youtube if that is easier for you.

 

[FrancisK7]

I will make a photo tutorial since I am photographer by day and therefore have all the equipment I need already. I was about to do another batch soon, so I'll document that and post when ready.

 

[F.u.Crohns]

I will make a photo tutorial since I am photographer by day and therefore have all the equipment I need already. I was about to do another batch soon, so I'll document that and post when ready.

sweet thanx!

 

[FullM3lt]

I got a strain with 10% CBD content and 10% THC that is curing right now.

Im really excited about trying it, never had CBD rich strains before.

My new ingestion preference is via an alcohol based tincture nowadays.

Let us know how it goes.

BTW its not anecdotal anymore, the ability of CBD to modulate and potentiate the effectiveness of THC is irrefutably demonstrated in the literature.

Is it a CBD crew strain by chance? I'm really enjoying these high CBD strains I have now. I'm linking up with a few people to get a few clones of the high CBD strains in my area soon If I remember correctly, you were in Canada, correct? Congrats on the medical program getting it's injunction for the growers.

I'm well aware of the literature on the subject, I think I said scientific and anecdotal. :ycool:

Anyways..it's been a few days. No huge differences yet, but I assume I wouldn't see any big differences until I got some more concentrated forms of the CBD. I will be getting some oil soon that is 45% CBD 23% THC.

Just a few small differences I've noticed...

I'm in a better mood. The CBD in combination with THC is extremely calming. It's a completely different experience. It's like having the calming effects of an indica with the clear headedness of a sativa but without the paranoia or anxiety involved with some sativa strains. It's not like a "high"...the best way I can describe it is sobriety enhanced. It's really different than high THC low CBD cannabis.

Another effect I noticed is all my joints become relaxed. I have TMJ and arthritis in my knee. After a vape bowl of the high CBD Harlequin mixed with some dry sift, my joints feel lubricated. It's an odd sensation...but it's nice.

I'm also sleeping much better. By that I mean I wake up feeling rested with less sleep. If I vape high THC strains before bed, sometimes I feel groggy in the morning. This isn't the case with CBD. I feel more awake and alert during the day, I stay up later and I wake up earlier. Seems like a paradox, but it's true.

My disease is not technically in remission, but it is extremely mild right now. (1-2 BM a day, blood 1-2 times a month) so I still have cramping and other mild symptoms involved. I have not noticed any major differences in my bowel movements, but I assume it's too early for that. If I want quicker results, I need to move on to a more concentrated version.

I will report back again in a few days. Hopefully I can grab some high CBD oil to boost my dosage. I figure if my Harlequin is 7% CBD by weight, then there is roughly 70 MG in a gram of dry flower. Of that 70mg, I'm probably getting 20-30 mg into my bloodstream (CBD has a low bioavailability for all methods of consumption) That's a lot of vaping just to get 20-30 mg. I can get more than that in 1 .1g dab of high CBD oil.

 

[F.u.Crohns]

If you want another High CBD strain look into " Canatonic " . That's the strain I been smoking for my flare up. Its 6% THC and 10% CBD on the testing some actually have higher cbd % it just depends.

Here is another good site to check out for high cbd strain and for info on it.

http://synergycbd.com/cdb-rich-strains/

 

[FrancisK7]

Yup, it's CBD Yummy.

Canatonic is a clone-only strain as far as I know, impossible to get where I live so couldn't grow it.

 

[FullM3lt]

Yup, it's CBD Yummy.

Canatonic is a clone-only strain as far as I know, impossible to get where I live so couldn't grow it.

Cannatonic is available in seed form from Resin Seeds. The CBD crew is actually a joint venture between Mr. Nice Seeds (Shantibaba) and Jaime from Resin Seeds. There are a bunch of different phenotypes going around in clone form...the strain "Charlotte's Web" is actually just a phenotype of Cannatonic.


Little update...my bowels have been kind. Almost too kind...since I started the high CBD regimen my #2's have been firmer and more formed than usual...which ended up aggravating a fissure :rof: SOOO painful, but I guess a fissure is better than a flare.

Having IBD sucks...even when it's in remission there is always something else going on with my body. I've only had one fissure previously (the one I just reaggravated) and it healed relatively quickly so I'm hoping for the same with this one. I just need to rest and stay hydrated.

I am seeing good results with the high CBD meds. Nothing drastic (since I'm already in remission) but things are slowly improving even more (aside from the fissure, which was caused by an unusually large and formed BM :ycool I didn't get a chance to grab that Harlequin oil I was talking about, but I will definitely report back when I get it.

 

[FullM3lt]

Little update...I think I went a little too hard with the CBD at first. It definitely slowed down my gastrointestinal tract and created larger, more formed stools. But that ended up causing a fissure!

I am going back to a lower dose of CBD and higher dose of THC until this heals up, then I will try again. I think CBD can offer a lot to people with IBD, I just had some bad luck with this fissure.

I do not think the CBD directly caused the problem. More indirectly. The high CBD regimen made my stools larger and more firm and apparently my b-hole wasn't ready for that!

 

[bert]

Actually, a tincture is more potent than an oil based delivery system by weight as alcohol's bioavailability is higher than oil's. I think Rick Simpson used oil because it's cheaper, much easier to get and the transfer is easier as well. You need 94% proof alcohol for tinctures (Everclear) and in Canada a 40 oz bottle costs north of 60$. Oil is a fraction of that price.

A solvent extraction method takes more step (it takes me 72 hours) but it removes ALL the nasty cannabis taste you find in edibles. You can either administer the tincture under your tongue for very quick action, or transfer it back into any edibles, but without the nasty after taste.

Once I discovered the method I never looked back. If you want I can make a detailed photo tutorial and post it here.

Looking at his youtube video, Rick uses high strength alcohol as a solvent for cannabinoid extraction. The buds are soaked in the alcohol for a short time before being evaporated in a rice cooker or similar until there is no solvent left. What he then seems to have is a thick highly concentrated substance which is ingested in small amounts about the size of a grain of rice to begin with. I think it is much more concentrated than a tincture but strictly speaking I am not sure it would really be classed as an oil. Personally I prefer the idea of a tincture as it seems easier and safer to make.

I know people also use oilive oil, glycerin ect for cannabinoid extraction but I think this is different to ricks 'oil'.

I would love to see a tutorial in making a tincture. I am currently using a vaporizer with some home grown CBD crew critical mass. As the tincture is delivered under the tongue and into the blood stream and doesn't go through the digestive system will it really be better than vaporizing which goes through the lungs and into the blood stream? I know the tincture will be more convenient and descrete. Also is there evidence to suggest that the cannibinoid extract, in whatever form, works better for crohns when it goes through the digestive system.

Cannatonic is available in seed form from Resin Seeds. The CBD crew is actually a joint venture between Mr. Nice Seeds (Shantibaba) and Jaime from Resin Seeds. There are a bunch of different phenotypes going around in clone form...the strain "Charlotte's Web" is actually just a phenotype of Cannatonic. .

I have a cannatonc female seed growing at the moment as well as some more cbd crew critical mass and dutch passion cbd skunk haze. The last 2 are very indica and look like fairly short flowering plants. The cannatonic is taller and more sativa and will take an extra couple of weeks I think. I like the CBD crew stuff and most of the lab reports that I have seen show a fairly consistant ratio of cbd/thc. I think the cannatonic shows greater variance with some plants having much higher thc or cbd.

 

[Mark180]

FrancisK7,

What do you do to decarboxylate? I tried a tincture of cannatonic at a ratio of 1 oz to 1 cup of Everclear. First I decarboxylated it @ 250 for about half an hour. When I take it I don't feel much. I'm just wondering if I am not going about this right.

 

[Brenden]

Very interesting how this plant that naturally grows out of the grown can induce remission. Good luck and keep us updated FullM3lt!

 

[FullM3lt]

Very interesting how this plant that naturally grows out of the grown can induce remission. Good luck and keep us updated FullM3lt!

Thank you for the kind words, Brenden

It really is an amazing plant...nothing has helped me more and I have tried almost everything available.

I've been using this plant exclusively for 5 years to control my UC...I definitely haven't been in remission the whole time, but I have way fewer flare ups and they don't last more than 2 weeks. I think I've had 3 flare ups in the past 5 years, and all of them lasted no longer than 4 weeks. One of them was when I stopped using cannabis for 3 months. A week after I started using it again, I was in remission again.

It's definitely not a cure, but it's the closest thing that I've found so far. CBD seems to be very promising used in combination with THC.

 

[Trevor]

Great thread

I've been mixing Cannatonic with 'normal' Indica strains like Afghani and Blueberry Jam and stuff and it's a bit hard to say if adding the high CBD specifically has helped but either which way I've never been this good off Pred.

 

[FullM3lt]

Alright guys, I think the CBD had nothing to do with my fissure. I think it had to do with my diet more than anything. Specifically Dave's Killer bread...once I cut that stuff out of my diet everything got a lot better. I was also getting way too much fiber (like 60 grams a day) so that didn't help.

Anyways, enough asshole talk...

I'm back on the CBD. I know some people in the medical cannabis community with access to strains like Charlotte's Web (It's called AC/DC here) so that means high CBD hash oil. I'll be using it daily in the mornings.

I'll be acquiring a few high CBD clones as well so I can supply myself. The cool thing about these CBD plants is that they are essentially hemp...which makes them 100% legal to grow. (Although I do have my medical recommendation...)

My new gastroenterologist is very interested in mmj and she wants to see what my colon looks like in January so I'm bumping up my cannabinoid intake now...specifically CBD. I am very excited to see what my colon looks like on a high CBD regimen.

I know there is not a ton of information out there on CBD and humans with IBD, but I am using this colonoscopy as my own little experiment. Should be interesting to see the results. I won't have much to report on till January, but I just thought I'd post to let you all know..

 

[rollinstone]

Any updates?

 

[FullM3lt]

Wow guys, sorry for the LONG LONG lag on my part. Life has been busy the last few months for me with school and work.

I've been staying steady on the CBD regimen, although I've found through trial and error that a 1:1 ratio of CBD to THC works perfectly for me. The stuff I have right now tests at 46% CBD and 38% THC.

I've been vaporizing this oil daily for almost half a year. The regular high THC oil was doing a good job on its own, but I literally have not seen a single drop of blood since I started the CBD oil. This stuff is absolutely amazing and everybody with IBD or any other inflammatory disease should have access to it.

I'm not saying that this is a cure, but it is the closest thing I've found in my nearly 15 years of UC. I haven't had a scope yet to really see how things are doing, but no blood and mostly formed stools for months on end tells me that something is working. I will be having a scope probably in August since I will have some time off....so I might not report back until then.

BTW, I'm still not taking any other medication. Just the oil.

Hope everyone is doing well, I feel like I'm in the best shape of my life

 

[clearlife]

Can you detail, which strain(s) are you currently using? What are their common names? did you stay with charlotte's web or did you switch to something else?
How many times a day?

 

[Seuxin]

Hello guys,

Thanks for this thread ! I live in France, and thc is forbiden. Nevertheless, i would like to be able to make my own CBD/THC tincture like you, FrancisK7 !

I just would to know what's the cost approximatively for producing CBD/THC tincture.

Could you please give me an average cost ( marijuana, alcool).
I would like to have an "idea".

Thanks a lot

Best regards,

Seuxin

 

[Ohpoo]

Wow guys, sorry for the LONG LONG lag on my part. Life has been busy the last few months for me with school and work.

I've been staying steady on the CBD regimen, although I've found through trial and error that a 1:1 ratio of CBD to THC works perfectly for me. The stuff I have right now tests at 46% CBD and 38% THC.

I've been vaporizing this oil daily for almost half a year. The regular high THC oil was doing a good job on its own, but I literally have not seen a single drop of blood since I started the CBD oil. This stuff is absolutely amazing and everybody with IBD or any other inflammatory disease should have access to it.

I'm not saying that this is a cure, but it is the closest thing I've found in my nearly 15 years of UC. I haven't had a scope yet to really see how things are doing, but no blood and mostly formed stools for months on end tells me that something is working. I will be having a scope probably in August since I will have some time off....so I might not report back until then.

BTW, I'm still not taking any other medication. Just the oil.

Hope everyone is doing well, I feel like I'm in the best shape of my life

This is great to hear! When you use % how much is that in mg of cbd and thc? Also, if this is the oil, do you see a difference in when you dose around meals?

Thanks!

 

[Seuxin]

Hello,

You just vape this 1:1 oil ? You do this oil yourelf ? Ou you bought it ?
I'm able to buy a 14% cbd e-liquide at a good price, but not up to 14%

If you have source, please share

 

[RunMomRun]

Actually, a tincture is more potent than an oil based delivery system by weight as alcohol's bioavailability is higher than oil's. I think Rick Simpson used oil because it's cheaper, much easier to get and the transfer is easier as well. You need 94% proof alcohol for tinctures (Everclear) and in Canada a 40 oz bottle costs north of 60$. Oil is a fraction of that price.

A solvent extraction method takes more step (it takes me 72 hours) but it removes ALL the nasty cannabis taste you find in edibles. You can either administer the tincture under your tongue for very quick action, or transfer it back into any edibles, but without the nasty after taste.

Once I discovered the method I never looked back. If you want I can make a detailed photo tutorial and post it here.

First day signing in to group, diagnosed Nov 2012... very interested in learning more from you on how to go about making the tincture for under the tongue ( it's difficult smoking with little ones eyes always on you, esp. Now that school is out, lol.

 

[darster]

First day signing in to group, diagnosed Nov 2012... very interested in learning more from you on how to go about making the tincture for under the tongue ( it's difficult smoking with little ones eyes always on you, esp. Now that school is out, lol.

Welcome to the forum!
I vaporize in the mornings, before my son gets up. After vaping, I take the accumulated "used" marijuana from each week and put it in a mason jar. Put in enough grain alcohol to cover the product, and shake it twice a day. Store it in a cool place for a few days to a week. Strain and dose with an eye dropper if you have one. I have found that I can get a pretty strong tincture this way, and use it to medicate when I am unable to vape.

 

[leica]

Wow guys, sorry for the LONG LONG lag on my
Hope everyone is doing well, I feel like I'm in the best shape of my life

Reading your thread has been very inspiring, I live in Florida and we just recently had MM legalized. I was finally able to get my medical records from the VA released and I have an appointment with a MM doctor on Saturday. Unfortunately FL law requires a 90 period once you see a doctor before I can actually get any MM, but I am so excited at the opportunity to be steroid free I can hardly contain myself.

I was discouraged at first because my gastro doctor dismisses MM as "just a cover up that doesn't solve anything" and have read articles online that say the same thing. But hearing how it works for real people living day to day is promising and gives me hope. I'm so excited to get started and hopefully I can start my own success thread in the near future.

Thank you so much for this thread, you have no idea how relieved I am reading about your results

 

[Seuxin]

Hello,

I have a crohn dissease and i'm using 25mg cbd oil a day ( i did my cbd oil from cbd paste 25%). I do my math and my onw caps, each caps = 25mg cbd. On caps at morning. No thc since i'm on remission. Do you think 25mg cbd a day is enough ?

 

[darster]

Hello,

I have a crohn dissease and i'm using 25mg cbd oil a day ( i did my cbd oil from cbd paste 25%). I do my math and my onw caps, each caps = 25mg cbd. On caps at morning. No thc since i'm on remission. Do you think 25mg cbd a day is enough ?

I think it's different for every individual. You will have to adjust up or down, depending on how you feel.