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I definitely have active inflammation.. I get woken up by nauseous pain every night after only 5 hours of sleep. That's why I'm eager to start the Skyrizi. I just hope it can help quickly and I can finally get a good sleep after months of hardly sleeping. My primary Crohn's symptom is really specific.. it mostly comes down to nauseous pain especially at night while sleeping... all emanating from that lower right quadrant of my abdomen at the terminal ilium region.