T-BET upregulation BB536 Probiotic

[mf15]

Seems that it can be up regulated with specific protiotic strains.
Mostly for UC ,but who knows.
Old Mike

http://onlinelibrary.wiley.com/doi/10.1002/ibd.20861/pdf

This stuff is on the market.
http://www.bioclinicnaturals.com/images/PIM/BioclinicUSA/Products/162__9459U-PS.pdf.pdf

trying to track it down.
http://webbernaturals.com/caen/products/3728/probiotic-with-bb536

found it
http://www.amazon.com/Bioclinic-Naturals-Probiotic-Pro-BB536-vcaps/dp/B006JT25Z4

also in baby jarrow dophilus
http://www.seacoast.com/babys-jarro-dophilus/jarrow-formulas/70-grams/p4841

Seems to be safe,does not eat mucus or translocate.
http://www.ncbi.nlm.nih.gov/pubmed/19638311

ALso in VSL#3

 

[steve55]

let us know if it works

 

[kiny]

ALso in VSL#3

the good one in VSL#3 is L. acidophilus, it drops PH a lot in vitro, which inhibits bacteria like AIEC, L reutiri and L. rhamnosus are even better at it, dunno if any probiotic brands have them

in vivo they don't do enough though, only nissle 1917 is strong enough, but I think it was forbidden now in the US or something, idk

someone wrote a paper about them a while ago:

 

[mf15]

vsl3 cramps me really bad.
Will try the BB536 it seems to work all by itself,according to the above study.
Old Mike

 

[kiny]

here is the paper of hers, I speak the language but maybe google translate can translate it

http://lib.ugent.be/fulltxt/RUG01/001/789/804/RUG01-001789804_2012_0001_AC.pdf

inulin can make AIEC worse in vitro, AX prebiotic (Arabinoxylan) makes it better cause it increases viscosity of mucus iirc

what's funny is that many studies have tried inulin, because of the increased butyrate, but it comes at a possible cost of increasing AIEC, any short term effects could be negated if it incraeses AIEC

 

[kiny]

all the bifi---xxxxxx bacteria are colon ones though afaik, dunno if you have CD or UC, or where, but I would try to get some lactic acid bacteria too if you have issues in the small intestine, bifido---- aren't in the small intestine afaik

 

[mf15]

I have UC,been down the inulin prebiotic route and probiotic route many times.
Inulin also makes me worse,and so do probiotics depending on the probiotic and
how much I take.
UC since 1980 so have done many things.
Old Mike

 

[kiny]

cool, I just realised that L. acidophilus has it's name from the low PH it lives in probably, never thought about that