Depends
When Ds took shots of mtx he was sick for 6 days then it was shot day again
When he takes mtx pills at 25 mg again he is sick for 4-5 days
At 20 mg pills he splits the dose 12 hours apart
Takes 2 mg of folic acid (folate )
Then is nauseous starting 24 hours afterwards
Not sure how long that lasts since he just deals with it now and pushes through
I can ask later
