Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset IBD

[SupportiveMom]

We found that VEOIBD patients carry heterozygous functional hypomorphic variants in components of the NOX2 NADPH oxidase complex. These do not cause overt immunodeficiency, but instead determine susceptibility to VEOIBD. Specific approaches might be developed to treat individual patients based on their genetic variant.

http://www.ncbi.nlm.nih.gov/pubmed/24931457

 

[Mangomamma]

Hi. I am new to the forum and really curious about your posting. Are you concluding from this research that it might be worth supplementing NADH or NAD or even glutathione as a means of treating the disease? I have some interesting anecdotal reports that I am weighing in my mind as to whether this might be a good route to go. Thanks for your consideration.