Definitely genetics + stress. Given my mom and sisters have Crohn's, I might have had a predisposition to Crohn's and during an extremely stressful time of my life, it reared it's not-so-pretty-head.
I lost my baby sister quite unexpectedly when she was 19, and two of my close friends, all within six months. Having done some soul-searching after these deaths, I decided it was time to end my 7-year relationship that had outlived itself by about three years. My ex-partner also became quite hostile and gave me a lot of grief as we tried to figure out a fair way to sell our house, etc. At the same time, I was working 65 hours a week at two fairly high stress jobs.
So...the convergence of all these events created an ideal atmosphere for the Crohn's critters to jump aboard and claim a space...