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Don't forget one important item. It takes at least 24 hours after sun exposure to convert to the active form of vitamin d in the skin. If you take a shower after sun exposure you will wash much of it off. I have a thread on here somewhere, on the subject. Old Mike

Increases TGF-Beta signaling ,down regulates SMAD7. Old Mike http://medicalxpress.com/news/2015-03-drug-crohn-disease-early.html much more http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407250 looks like they knew this stuff back in 01 and prior, took this long...

Here is the best IBD history I have found. Notice the increase from about 1890-1920 and onward for UC. Dose not specifically talk about famous people. Takes sometime to load. If you want famous people here is one. Eisenhower had crohns, he shook my hand around 1951 or so, I might have been 3...

Here is something for you but not sure where it might lead. You can search google and pubmed for all kinds of info. Of course they find a million things wrong with our immune response, the question is what is really wrong. OM http://www.ncbi.nlm.nih.gov/pubmed/3873371

I suspect vaccination. But increases in IBD happened before widespread vaccination. Except perhaps smallpox. Of course vaccination may be one of the additive factors that is going on today. Old Mike

Cronhnic:This is the best history on IBD I have been able to find,been researching this dam disease for 35 years now. Anyway pay particular attention to the time period roughly 1890-1920 with the increase in cases in the British hospitals. Sure some of the increase was from better medical...

The Faroes import much meat from Demark which is a high MAP area. Here is a little something on Indian goat herders. and MAP. Old Mike http://www.ncbi.nlm.nih.gov/pubmed/21703899

Crohnick: Perhaps. Been looking for reasons to have low glutathione, loss of redox protection may set off UC,by destroying basement membranes first,then letting in the bacteria past a weakened mucus barrier,then setting off the immune cascade. I supplement with arginine which directly leads to...

In china unsterilized water is associated with less IBD. The incidence of IBD really started to increase somewhat 1900-1920. As far a the increase in kids, the gut microbiome is more unstable when young. The Faroe Islands have the highest IBD incidence in the world, if that can be figured out...

If I want a paper I cant get I track down the corresponding author or lead author. Send them an email, saying that you are a laymen researcher with IBD and are interested in there work. Could they send you a pdf of the complete paper. Be nice and thank them much for their work. I have received...

Combine this with emulsifiers and perhaps you have a mess. While this might explain the increase in incidence since about 1945 perhaps does not explain rise since about 1900-1920 unless some form of modified starch was used in food,might try and research that. Old Mike Deregulation of...

Things are just not as simple as they might seem. Early onset crohns dysbiotic while UC is not. In UC it takes up to 5 years to become fully dysbiotic I have posted this somewhere. Old Mike http://www.ncbi.nlm.nih.gov/pubmed/23044767

Interesting,explains some current thinking on gut bugs. I still find it fascinating that many of the mainstream drugs suppress MAP, and since 1942 the docs did not know it,until a few years ago. Old Mike http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325296/

Just make sure when you get your levels checked, they don't report d3 or d2. You want the test to report active vitamin D. Vitamin D deficiency (serum 25-hydroxyvitamin D < 20ng/ml) http://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/ Old Mike

I have the UC and my son has it, the wifes colon is pristine, go figure. Old Mike

From this small trial it looks like 5000 iu a day is needed. Old Mike http://www.nature.com/ctg/journal/v4/n4/full/ctg20131a.html

No or modest improvement was seen in patients who did not engraft or whose microbiome was most similar to their donor. What is going on with a similar microbiome to the donor, I wonder. Old Mike

Well actually it looks like in early onset kids there is an overabundance of Faecalibacterium Prausnitzii which is conflicting with adult CD. They really are somewhat puzzled by the results. Decide for yourself I guess. Old Mike http://www.nature.com/ajg/journal/v107/n12/full/ajg2012335a.html

There is no commercial product because they die when exposed to air. So like I said if your immune system has not killed them off you can increase with riboflavin/vitamin B2. Old Mike

First we are missing some Faecalibacterium Prausnitzii,anerobes in both UC and crohns. In UC http://www.gastrojournal.org/article/S0016-5085(11)60576-3/pdf in crohns http://www.ncbi.nlm.nih.gov/pubmed/23829084 http://www.ncbi.nlm.nih.gov/pubmed/23216550 How do we feed them...