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I agree with it. Not every Crohn's patient has NOD2 anomaly.

@kiny - Thanks for your response. The AIEC behind Crohns seems a logical and plausible explanation. If this is the cause, then why is it that the medication for Crohns keeps on going for the entire lifetime. Assuming that once the patient is in remission from Crohns, then the assumption is that...

@kiny - A question - It seems that AIEC can cause Crohn's in a very short span of time. However, I am reminded of a study which was done which showed that the gut microbiome changes in patients years before the onset of Crohn's. I have pasted the link though I am not sure if this is correct...

https://www.austin.org.au/news/crohns-breakthrough/ https://florey.edu.au/news/2023/12/first-in-human-implantation-of-bionic-device-to-halt-crohns-disease/ The question that I have is that if one patient is enough to make such a claim and how long do they have to monitor this patient post...

https://www.sciencedaily.com/releases/2023/10/231026131554.htm Interesting research. The question is how soon can we have newer medications and clinical trials?

https://www.fiercepharma.com/pharma/takedas-stem-cell-crohns-disease-treatment-alofisel-flunks-phase-3-trial This news is not good because phase 3 trials have failed.

I did NOT know that. That makes it really serious. Any studies which show why the patients die from the transplant?

https://reports.mountsinai.org/article/gi2023-02-stem-cell-transplants-for-crohns-disease I hope for more research in this area.

https://www.newscientist.com/article/2392304-key-immune-cells-may-help-protect-against-inflammatory-bowel-disease/ Interesting research but no idea if it will be able to deliver any new medication.

@ARSalerno3. I am not a trained medical professional therefore I don't need to see any of your reports. It is important to find a Gastroenterologist who you can trust. All I can say is I wish you all the best in your journey ahead.

@ARSalerno3 - the way to diagnose Crohn's disease is via a colonoscopy and endoscopy and a biopsy. Colonoscopy is done by a Gastroenterologist. I suggest you schedule an appointment with a gastroenterologist.

@Waldo - No insight just a suggestion. Do some physical activity on a regular basis if possible. It could be walking, running, swimming or dancing. I put out dancing because it can be a lot of fun and you get to make friends. I had read an article about dancing on cnn. It is your journey, you...

@Waldo -All the best. It is a journey and it will take time.

It is perhaps one of the biggest challenges of Crohn's disease. How and why does the body find a way around a treatment which has worked in the past?

I agree that Crohn's disease people will have all sorts of bugs because of the fact epithelial barrier is breached. The other problem is that when the intestines are suffering from inflammation, it is not possible for probiotics to reach the intestines. And it is also possible that even if a...

@sjiadad - I hope your son is feeling better. It has been a while since your last update and I wanted to check with you how is it going.

Hi - I am sorry to read about your recent diagnosis. The only thing I can state is, if in doubt, talk to your gastroenterologist. Your GI can guide you through heaps of questions which you will have related to your medications, diet etc.

https://www.medicalnewstoday.com/articles/an-oral-inhibitor-could-provide-a-new-therapy-for-inflammatory-bowel-diseases https://www.science.org/doi/10.1126/scitranslmed.abn7491

I came across this article recently: https://www.cbc.ca/news/canada/british-columbia/air-pollution-ibd-study-1.6940146 I have long suspected that use of pesticides in our food chain is something which was never explored. This study goes further and links air pollution too. Below are some...

I agree. If the epithelial integrity is breached, it will allow all sorts of bacteria, fungi to get into the gut. However, if there is a way to restore the balance during that time, it will be extremely useful because diets such as EEN, CDED are trying to do just that. So far the researchers...