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https://www.managedhealthcareexecutive.com/view/the-path-to-shortening-long-covid-may-go-through-gut For reasons that aren’t entirely clear, long COVID is associated with diminished microbial diversity in the gut and a decrease in several healthful strains of bacteria, such as Bifidobacterium...

dysbiosis, a universal cause, a few links of many that i've saved https://pubmed.ncbi.nlm.nih.gov/34229263/ Supplementation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind...

houston, 28c and humidity on the climb. the end of our best weather is near. sporting a nice tan from the last few days :) dreading the spring and summer temps coming up

mlp, you have this medical stuff locked down. smart like a computer (y)

thanks for the link! there is a lot of activity in microbiome research for all kinds of diseases. diseases that have been shown to be caused by gut issues. they are on the right path (finally). the future is bright!

ibd = low bifids = bad covid outcomes it's been found that the bioweapons target/destory the bifid bugs in our guts. some researchers say they can predict covid outcome based on the number of bifid bugs alone. this is also the cause of so-called long covid. the bifid bugs have been decimated...

replies above in bold. updated with edits 4-14-24

i would love to help with your study, but i dont make the cut. i dont think many here are in the age bracket. good luck!

https://pubmed.ncbi.nlm.nih.gov/27548430/ The Search for Causative Environmental Factors in Inflammatory Bowel Disease The best investigated environmental factor identified in IBD cohort analyses is smoking. Other environmental factors that have been associated with clinical presentation or...

they are figuring it out. twins case shows not genetic, but epigenetic (prone to) https://www.mdpi.com/1422-0067/24/4/3817 2. Gut Microbiota and IBD Currently, in Europe and the United States, 3.6 million people suffer from IBD, including UC and CD, which are becoming increasingly prevalent...

imo it appears that i am dominating, but is that not because of a lack of activity from other posters? reading some of the old threads, it appears the board used to have a lot more activity and active members. i've seen that fade in other forums too. is it because the hive think gets trite...

thanks for the reply. maybe a little background will help -- i try to limit most of my work to the subforum of research, so as not to clog up the others. methotrexate is near/dear to my story. it was the drug my rheumy was pushing on me. thusly, i did quite a bit of research on it back...

this one wouldnt let me paste. it discusses translocation from mouth bugs. and that leads to dybiosis and leaky gut https://www.rdhmag.com/patient-care/patient-education/article/14284883/the-translocation-of-bacteria-inflammatory-bowel-disease

butyrate shortage, ie, shortage of butyrate producers, like the bifid family of bacteria https://academic.oup.com/ibdjournal/article/16/7/1138/4628425 Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate The gut microflora in some patients with...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452966/

aka, pathogenesis https://gut.bmj.com/content/59/10/1331 Results E coli translocation increased across M-cells compared to parent Caco2-cl1 monocultures; 15.8-fold (IQR 6.2–32.0) for Crohn's disease E coli (N=8) and 6.7-fold (IQR 3.7–21.0) for control isolates (N=5). Electron microscopy...

a couple of more options from a pharmacist that studies all of this stuff. he said that aloe juice, slippery elm, and noni juice are good for leaky gut. according to him they help coat the system and tamp down inflammation, promoting healing

summary of trials with certain species of bacteria https://pubmed.ncbi.nlm.nih.gov/28294322/ Altered gut bacteria and bacterial metabolic pathways are two important factors in initiation and progression of inflammatory bowel disease (IBD). However, efficacy of probiotics in remission of...

good results with common strains of beneficial bacteria in a mouse trial https://pubmed.ncbi.nlm.nih.gov/36715169/ A Novel Probiotic Combination Ameliorates Crohn's Disease-Like Ileitis by Increasing Short-Chain Fatty Acid Production and Modulating Essential Adaptive Immune Pathways...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954989/ Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation We show that MTX broadly alters the human gut microbiota. Drug sensitivity varied across strains but the mechanism of action...