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Some newer studies point to ACE (adverse childhood experiences) as a cause of increased inflammation. This is related to chronic stress, which is a consequence of emotional trauma. If a whole family is dysfunctional (alcoholism, abuse, emotional unavailability etc.), or both parents are severely...

Could it be ACE, which causes chronic stress, is the primary environmentel factor? And that our genetic profile results in our gut being the a weak spot, leading to IBD. While other genetic profiles may lead to other inflammatory diseases elsewhere in the body?

This meta-study from 2015 on the subject is interesting: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564950/. The study concludes: The present meta-analysis finds a significant association between childhood trauma and the inflammatory markers, with effect sizes being greatest for TNF-α...

In the last decade I have seen more focus on family related (emotional) trauma / neglect as a causal factor. I asked ChatGPT this: What is the trend in research into whether adverse childhood experienced (ace) is a causal factor in inflammatory disease? Is more or less research being published...

Crohn2357, no, and I have stopped following the research, so I am not the right one to ask :) maybe others here have been keeping up?

Crohn2357, no, and I have stopped following the research, so I am not the right one to ask :) maybe others here have been keeping up?

The placebo effect tells us there is a psychological component to inflammatory bowel diseases. It seems that traumatic events can lead to physical illness, and that being cared for (by others or oneself) can dampen symptoms. The field is called psychoneuroimmunilogy (PNI) and is worth following...

I agree. The silver bullet must be a way of permanently getting rid of the pathogens. I think it must be a tree step process: 1) get the body in the best possible state: no stress, healthy diet, exercise. 2) knock down the pathogens (AIEC and ??) - with a drug that unfortunately does not exist...

Thanks, I got a similar impression, that the combination of antibiotics helps some patients, while others see no effect. The high doses and long duration of treatment is tough for some, it seems. For me that uncertainty and the side effects makes anti-MAP therapy less attractive to try.

Thanks for sharing. I have followed the MAP research for many years now. It was a setback that Prof. John Hermon-Taylor died, but great to see that the Human Para Foundation is still active and that Dr. Chamberlain / John Aitken continues to do research. I sent off blood samples to Aitkens lab...

Well that blend I mentioned above only made it worse. I stopped and I am now focused on getting rid of some mayor stressors in my life. I suspect stress plays a much bigger role in my IBD than I have been aware of.

Thank you very much for sharing this. Just had a go at it, and its not that bad. For a batch I am using dextrose (150g) but I exchanged the whey for soy protein powder (40g) because I'm eating plantbased, and cold pressed coconut oil (33g) because I could not find MCT oil in any store. Also, I...

Patulsius, would you be willing to share your home made recipe?

Another piece in the "origins of stress" puzzle, the diagnosis "CPTSD", short for Complex Post Traumatic Stress Syndrome is now (since 2018) accepted as a psychiatric diagnosis. Prior there was no diagnosis to cover the mental sickness and chronic stress that arise from continuous trauma (eg...

Thanks J100 :) it would be interesting to hear if you have any experience or insights.

A short follow up on this thread. I have read enough now to realise the potentials in improving my Crohns disease (CD) my addressing and healing childhood trauma. So I have decided to go down the road of extensive therapy to try and heal my traumatic stress. I can think of four possible outcomes...

What a coincidence Delta hippo. I seriously just ordered that book 20 minutes ago, right before viewing this post!

I should add that the healing process as defined in ACA and Matés proposals does not involve looking upon ones situation as being a victim. That means the way forward is not blaming parents, siblings, perpetrators - and one self. Rather the therapeutic effect comes from recognizing, with...

The role of chronic stress in immune diseases seems to be a topic that gets some attention at present. Nature published these within the last year: Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment Chronic stress can inflame the gut — now scientists...

Hi Bufford. That does not sound like the best approach to me. If you suppress your (healthy) anger towards other people, the suppression will lead to chronic stress. May I suggest seeing a lecture by Gabor Maté (YouTube) or buying his book "When The Body Says No". He is a phycisian /...