Anaphylaxis Humira or Remicade atopic kids

[my little penguin]

I realize both drugs(humira or Remicade)can cause anaphylaxis in otherwise "normal" kids/adults.

Ds has had anaphylaxis before to food. He is highly atopic and has asthma.

So I am trying to research with all other things being equal ( which I know they aren't).

IS one drug been studied to be more likely to produce Anaphylaxis in atopic individuals ?

:sign0085:

 

[imaboveitall]

Allergic reactions are FAR more frequent w/Remicade than Humira.

 

[DustyKat]

:lol: You pipped me at the post Julie! :thumleft:

I personally haven't come across any such studies lmp but have a look at the links here and see if anything comes up when you search.

Dusty. xxx

 

[imaboveitall]

:ysmile: at "pipped"

 

[my little penguin]

Approximately 20% of REMICADE-treated patients in all clinical trials experienced an infusion reaction compared with 10% of placebo-treated patients [see Adverse Reactions (6.1)]. Prior to infusion with REMICADE, premedication may be administered at the physician’s discretion. Premedication could include antihistamines (anti-H1 +/- anti-H2), acetaminophen and/or corticosteroids.

From:
http://www.remicade.com/hcp/remicade/assets/hcp_ppi.pdf

versus:
HUMIRA

In clinical trials of HUMIRA in adults, allergic reactions overall (e.g., allergic rash, anaphylactoid reaction, fixed drug reaction, non-specified drug reaction, urticaria) have been observed in approximately 1% of patients.

from:
http://www.rxabbott.com/pdf/humira.pdf

Of course the Remicade one includes all reactions not just Anaphylaxis
but I am just going to do some more digging.
:cool2:

 

[my little penguin]

Among all REMICADE infusions, 3% were accompanied by nonspecific symptoms such as fever or chills, 1% were accompanied by cardiopulmonary reactions (primarily chest pain, hypotension, hypertension or dyspnea), and <1% were accompanied by pruritus, urticaria, or the combined symptoms of pruritus/urticaria and cardiopulmonary reactions. Serious infusion reactions occurred in <1% of patients and included anaphylaxis, convulsions, erythematous rash and hypotension.

A little better less than 1% but nothing on already atopic people

 

[my little penguin]

So I asked some friends to do some higher level pHD type "digging" for me
and to paraphrase-

Remicade (Infliximab) has a reported incidence rate of anaphylaxis of ~1.5% of
injections in children and adolescents. This rate appears to be the same in
several studies.

Humira is a fully human monoclonal antibody to TNF-alpha, and has been used to treat patients allergic to Remicade. Humira(Adalimumab) does not appear to be associated with a significant risk of anaphylaxis (although there is always a
small risk ).

So if a biologic is needed for DS given his history of anaphylaxis to food and reaction to contrast dye I will be pushing for Humira at this point.

I am going to put my head in the sand on all the potential "other" things that could go wrong since at this point we are running out of possible drugs to even try. :hallo3:

 

[izzi'smom]

Your head is totally not in the sand...you know the risks and the potential outcome is a better option than the risks (plus the rates of remission/probability of it helping are far better than the chance of a side effect).
I am trying to say don't feel bad...you are doing the best you can!!
I have heard of far more reactions on Remi...the only complaints I have heard firsthand re: Humi are injection site reactions.
Best of luck if you *do* decide to go with it! I know it can be a super hard decision.

 

[Spooky1]

must say, my throat swoll up for a few days after injecting Humira. was nigh impossible to swallow anything. quite stiff and painful, so i came off of it.