kiny
Well-known member
- Joined
- Apr 28, 2011
- Messages
- 3,463
I just want to point this out.
If you take antibiotics for crohn (not for complications like fistula), your doctor and you basically agree that crohn is a manifestation of a pathogen taking advantage of the immune deficiency crohn's disease patients have.
But it's really likely that corhn is not one single disease, they find not only MAP but also E Coli and not just one type of E Coli, thanks to new tech in the last years they are finding many different strains (they do not find these in controls). All of those pathogens are able to induce inflammation and an immune response, but because one person has inflammation and they see a granuloma reaction from a pathogen, does not mean that the other person with a granuloma reaction has the same pathogen, you can't tell what a person has by only checking inflammation.
There are different kinds of antibiotics, some are macrophage-penetrating, some are not. Some create very high resistance, some do not.
If you take an antibiotic, your doctor should know what bacteria you have and should know the resistance the bacteria is going to create. He needs to know, if he does not know, you are screwing yourself over because you are making the bacteria way stronger instead of actually killing it.
I have seen many people say that Flagyl worked for 1 month and then it does not. The reason for that they think is because you used monotherapy and you created resistance. So next time you try another antibiotic, a macrophage-penetrating one, you might be screwed, because the use of one antibiotic influences how another behaves.
Most GI have no clue what crohn is, they give antibiotics without knowing the bacteria and without knowing the effects on people. Biopsies and serum tests should be done before you start antibiotics so they know which strain they are dealing with, so you're not screwed later on, in many tests they are seeing that people with prior monotherapy Flagyl or rifaximin use, that macrophage-penetrating antibiotics do not work, the reason is the prior use of antibiotics that failed.
Clinics who are not used to antibiotics use for crohn have no clue what they are doing. The use of Flagyl monotherapy of rifaximin monotherapy might be very detrimental to macrophage-penetrating antibiotics.
great article related to it here:
http://www.ncbi.nlm.nih.gov/pubmed/22508665
If you take antibiotics for crohn (not for complications like fistula), your doctor and you basically agree that crohn is a manifestation of a pathogen taking advantage of the immune deficiency crohn's disease patients have.
But it's really likely that corhn is not one single disease, they find not only MAP but also E Coli and not just one type of E Coli, thanks to new tech in the last years they are finding many different strains (they do not find these in controls). All of those pathogens are able to induce inflammation and an immune response, but because one person has inflammation and they see a granuloma reaction from a pathogen, does not mean that the other person with a granuloma reaction has the same pathogen, you can't tell what a person has by only checking inflammation.
There are different kinds of antibiotics, some are macrophage-penetrating, some are not. Some create very high resistance, some do not.
If you take an antibiotic, your doctor should know what bacteria you have and should know the resistance the bacteria is going to create. He needs to know, if he does not know, you are screwing yourself over because you are making the bacteria way stronger instead of actually killing it.
I have seen many people say that Flagyl worked for 1 month and then it does not. The reason for that they think is because you used monotherapy and you created resistance. So next time you try another antibiotic, a macrophage-penetrating one, you might be screwed, because the use of one antibiotic influences how another behaves.
Most GI have no clue what crohn is, they give antibiotics without knowing the bacteria and without knowing the effects on people. Biopsies and serum tests should be done before you start antibiotics so they know which strain they are dealing with, so you're not screwed later on, in many tests they are seeing that people with prior monotherapy Flagyl or rifaximin use, that macrophage-penetrating antibiotics do not work, the reason is the prior use of antibiotics that failed.
Clinics who are not used to antibiotics use for crohn have no clue what they are doing. The use of Flagyl monotherapy of rifaximin monotherapy might be very detrimental to macrophage-penetrating antibiotics.
great article related to it here:
http://www.ncbi.nlm.nih.gov/pubmed/22508665
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