Hello, I give myself my B-12 shots Bi-Weekly 1mcg. To be honest I don't notice a difference. I started out taking it once a month, after no results in added energy it went to bi-weekly, still no change in energy. I stay completely drained, its like I need a bump of speed to function (totally kidding lol) but for real, maybe everyone is different, I have a B-12 deficiency so idk. Just my input.