Caffeine suppresses TNF-alpha production

[pieface]

https://pubmed.ncbi.nlm.nih.gov/153... activation of the cyclic,Int Immunopharmacol
'To conclude, this study demonstrates that concentrations of caffeine that are relevant to human consumption consistently suppress production of the proinflammatory cytokine TNF-alpha in human blood and that this effect is mediated by the cyclic AMP/protein kinase A pathway.'

There's a few natural substances that have evidence of anti TNF-A activity, most commonly known is probably curcumin. I was unaware that caffeine had this effect.

Might experiment with alternate delivery methods to avoid intestinal discomfort. Anyone try caffeine patches?

 

[James02]

Very interesting. I've always had coffee in the back of my mind as an underlying culprit to my issues. Curious what others think.

 

[jadegreen]

Also interesting. I eat dark chocolate every day en lieu of coffee, and it's sat just fine with me. I have had the sensation that it's something I actually need--mostly for my mood and alertness. But this article brings up an interesting possibility to me.

 

[kiny]

Might be interesting to add that anti-TNF agents often don't work for crohn's disease and are known to paradoxically induce crohn's disease.

Infliximab can induce remission, many others can not.

Etanercept is a very potent anti-TNF inhibitor. But, not only does it not work for crohn's disease, at all, it paradoxically can lead to the development of crohn's disease.

TNF-a is a complex cytokine which interacts with many cells, involving processes we don't fully understand.

 

[pieface]

Might be interesting to add that anti-TNF agents often don't work for crohn's disease and are known to paradoxically induce crohn's disease.

Infliximab can induce remission, many others can not.

Etanercept is a very potent anti-TNF inhibitor. But, not only does it not work for crohn's disease, at all, it paradoxically can lead to the development of crohn's disease.

TNF-a is a complex cytokine which interacts with many cells, involving processes we don't fully understand.

OK.

How about I buy empty enteric coated pills (resistant to stomach acid), then fill them with coconut oil and swallow a fuck tonne?

OR, any recommendations what else I could fill them with that might work locally?

 

[Papantoine]

I too, would be suspicious at the idea of the health benefit of caffeine especially that in teas, matte or coffee (and definitely not in the red bull types)

But there is a place in Toronto called Chocosol that makes natural dark chocolate unprocessed (not dutch) the traditional mayan way and they used to drink it as a « warrior’s » drink.

I sometimes would get a 100% fully dark chocolate drink and it really felt good. Healthy.

So yeah, maybe look in to getting some actual cocoa. I used to munch on cocoa beans too. Just pure cocoa. And it felt good.

Not sure about the real health value but I know there is some caffeine in it.


Of course, it would be at best a hollistic add on, like herbalism, essential oils, teas, yoga or any other natural remedy, a lot of them help a bit in small amounts but don’t do them INSTEAD of actual treatment. Just as an add on for good health.

That’s my 2 cents on caffeine. (from dark unprocessed chocolate)