Crohn's disease as a chronic oral infection.

[kiny]

It's the theory that Klebsiella p. found in the intestine of crohn's disease patient comes from the mouth, acts as a reservoir, and can reinfect patients. I linked some studies like these before. What makes this theory somewhat intriguing is that many people with crohn's disease have aphthous ulcers, for which we have no explanation. What is also a bit intriguing about this theory is that you could of course just take a biopsy from the mouth at that point, to predict disease progress, to administer the right phages, etc, basically a very non-intrusive method.

 

[asadmom]

Found this @kiny -> https://www.bristlehealth.com/

I have been following these two ladies as they embarked on the journey to treat themselves:

They are doing an incredible amount of testing, most provided by the sponsors.

 

[kiny]

https://www.nature.com/articles/s41575-021-00488-4

In this Perspective, we propose that in inflammatory bowel disease, oral disease-associated bacteria translocate to the intestine and directly exacerbate disease.

Would be a good idea if people on EN rinse their mouths thoroughly with plain water after each drink. It's always possible that EN works because it's aqueous and therefore has an impact on the oral cavity.

I don't know how solid and liquid food habits impact the bacterial load in the oral cavity, but it would be silly if the elephant in the room was that EN lead to remission because EN is simply fully soluble, and study after study missed this. EN that is prepared too viscous might not be so effective then.

There's always been people on the forum who claimed that putting their food in a blender and drinking it helps them control their crohn's disease. I don't know what not chewing on food and just chugging down a liquid does in the oral cavity, but it has to have some kind of impact on oral bacterial populations that depend on accessible carbs.

I have always been interested in knowing why people with crohn's disease develop aphthous ulcers and why it coincides with disease activity. I had these ulcers too in my mouth. This does not happen during foodborne infections or intestinal TB afaik. It is a typical feature of crohn's disease that has been largely overlooked.

 

[asadmom]

This is very interesting: Path connecting periodontal disease with RA

 

[asadmom]

Found a company that makes oral probiotics: blisprobiotic.

 

[westernbuddy]

I think some brands of protein shakes trigger flares in some patients with crohns, this adds to the confusion as they are liquid.

 

[asadmom]

I think some brands of protein shakes trigger flares in some patients with crohns, this adds to the confusion as they are liquid.

Why does it trigger inflammation?