I have been on Asacol since around June 2012. It helped a lot with abdominal pain and joint pain but didn't do a lot for suppressing the rectal irritation and bleeding. I had used steroid foams and suppositories in the past without very good results. My doctor prescribed Canasa suppositories but said they can only be used for 6 to 8 weeks. He said any suppository or topical medication rectally for extended periods thin the lining of the membranes and could cause irritation. The Canasa worked great but after six weeks I still had very mild irritation so I stopped it and switched to Anusol once a day. All of the inflammation is gone after about a week and a half of the Anusol. I didn't think to ask my GI how soon I can use the Canasa again if I need to but I plan to when I see him again or I can call any time and leave him a message. I was curious if there are any others here that have experience with Canasa and what regimen may have worked.