Detection of mycobacterium avium subsp paratuberculosis (MAP) in crohn, Mexico.

[kiny]

http://www.docstoc.com/docs/121888475/Detection-of-mycobacterium-avium-subsp-paratuberculosis-in-crohn-s-disease-patients-and-ruminants-intestine-by-in-situ-hybridization

Group A with 8 samples showing a granulomatous reaction and ZN (+); and group B with 4 samples showing granulomatous reaction but ZN (-).
Group C included those Crohn’s disease cases in which at histopathological examination we observed transmural inflammatory infiltrate with the presence of macrophages, epitheliod cells and sometimes giant Langhans cells; and considered as granulomatous. Whereas group D consisted of those cases in which infiltration was predominantly lymphocytic with plasma cells or mixed with some granulocytes at mucosal or transmural level which were considered as non granulomatous. In a single case with multiple samples, one was classified within group C and another one in group D. Group C consisted of 7 patients and 10 samples, whereas group D comprised 8 patients with 13 samples.

Results:

In the ruminant groups A and B, as expected, all the samples were positive by in situ hybridization. In humans (groups C and D), overall positivity for
M. avium subsp. paratuberculosis by in situ hybridization was 64.28% (n= 9). According to the groups distribution, all 7 patients (100%) in group C were positive for M. avium subsp. paratuberculosis by in situ hybridization, compared to 3/8 (37.5%) patients in group D; this difference was statistically significant (p= 0.0239)

 

[handle]

Quoting from that very minimal study, of only nine patients:

"Of the 8 patients in which more than one sample was analyzed, 3 of them were positive, 2 (25%) showed one positive and one negative sample and in 3 cases (37.5%) all were negative."

That's quite a poor correlation really, and as the author's indicate, not indicative of any causal association to the disease.

 

[David]

Kiny, please avoid the personal attacks. I've removed your access for two days so you can calm down. I realize you're passionate about the idea of MAP but everything posted here is open to debate and discussion and handle was doing nothing wrong or out of the ordinary. In fact, what he is doing is very appreciated.

Thank you and I hope you continue to share in a couple of days.

 

[handle]

Kiny, you misrepresent the article:-
Groups A and B were cattle with John's Disease, not humans! They are control groups.
Clearly you don't properly read your own articles, and hence misunderstand what is being presented.
I have done no 'spin' at all. I have quoted directly from the article which you linked.

Try to understand that the mere presence of a bacteria which is commonly found in the environment, and often in the intestinal tract, is not particularly relevant. There are many bacteria found in the intestinal tract. It is the causal link to illness which is important, and that has not been shown.

Your insulting remarks are an indication of your misunderstanding, and do my best to tolerate them.

(oh, I noticed you stepped in there David, thanks.)

 

[Igor_Passau]

thank you for the info!