Even if it is MAP...

[Sea_Star]

and you eradicate the pathogen/bacteria, wouldn't you still be susceptible to acquiring it again? Just like you have recurring bouts of pneumonia or H Pylori...?

Ugh, can we all just get on a plane funded by the CCFA or FDA and go see Dr. Borody in Australia? lol.

It's difficult to not have closure or not being able to get to the bottom of things.

 

[kiny]

If it really is MAP, you'd just get reinfected sure, it's omnipresent in the foodchain and environment. But what would it matter if you had treatment for it. The incubation time for MAP is years, and you'd need chronic exposure, if someone got sick again, you'd just treat the person again like you do with other mycobacteria like TB.

 

[Sea_Star]

Hm, do you think treatments for that are more harmful than immunomodulators or Biologics? I know it can mess up your kidneys, but if you can treat the pathogen, then have some antibodies (vaccine?) to it, would you be set for life?

That's interesting about the incubation period...didn't know that! I thought it was more immediate than that...

 

[kiny]

It would depend on the treatment. Chronic use of antibiotics is bad for your liver or kidneys, and many of the currently used antibiotics that work against MAP overlap with TB antibiotics. What happens if you get TB during those years of treatment? Not a good time to get TB.

MAP has a long incubation period because unlike other mycobacteria, it divides extremely slowly. This is why it takes months to culture it, and why it's so hard to kill with antibiotics, many antibiotics work during cell division. An antibiotic that can kill map would be able to kill non-dividing cells.

A vaccine would be safe if it worked.

 

[Matrix]

A vaccine would be safe if it worked.

let's hope it will work

http://crohnsmapvaccine.com

 

[Kev]

If the incubation period was years, then either MAP isn't responsible for IBD in newborns, infants... or it crosses the placenta barrier. I've read posts on here where babies who were 3 months, 6 months, 10 months were diagnosed.

A very slow incubation period would explain why treating with short course anti-biotics isn't effective. A vaccine with a long time frame between booster shots should work. IF all IBD was the result of the same bacteria.

Wouldn't it be simpler to quarantine all animals in the food chain that were diagnosed with MAP? Or at least more cost effective? IBD doesn't appear to transmit human/human, (except maybe the placenta barrier scenario mentioned earlier)... so if we eradicated it from our food supply... couldn't we break the cycle?

 

[Clash]

I don't know why the causation has to be the same for each person. I mean if you believe MAP is the cause then you would have to be open to other intracellular bacteria being the cause. Some who believe in MAP think remicade works for CD because it causes apoptosis which would help control the intracellular bacteria. But there are people that remicade or the other anti tnf blockers don't help at all so maybe the etiology of their disease is completely different.