Found interesting connection between Crohn's/E. coli

[num1habsfan]

I have been working on my final exam for health studies class, which I hand in tomorrow. We had research two contagious diseases that are affected by global warming in western Canada. The trick was that they had to be topics which nobody else would have (so basically the least discussed).

My strategy was thinking of diseases I had and how they could be affected by global warming. One of them was how global warming decreases the spread of Candida.

For the second one, what I found for Crohn's was that there was a strong correlation between Crohn's and E. coli. If you guys haven't seen this article, you should read it...I think it is interesting.

There was another in-depth journal article but I can't link it because you have to be logged in to the university

 

[D Bergy]

My personal experiment in killing mutant strains of E-Coli pointed me to the same conclusion that E-Coli plays a role in symptoms.

When I targeted these organisms using specific frequencies thought to kill them I got sick. I did it again to rule out coincidence, I got sick again.

I had others that use this method try it on themselves. It produced no reaction. I did not know what to make of it at the time, as I was still undiagnosed, but later on I put it together with the help of similar research.

Interestingly, now that I have treated for this bacteria and others, I no longer have any reaction to the very same treatment that made me sick twice before.

I would take this research seriously. The odds of my experiment being a adverse reaction unrelated to the bacteria are quite small. The real researchers are on to something in my opinion.

Dan

 

[num1habsfan]

Ohh, thanks for believing in it, Dan

I was able to find the link:Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer.

If that doesn't work, here's what main paragraph said:
"theBACKGROUND & AIMS: Altered mucosal glycosylation in inflammatory bowel disease and colon cancer could affect mucosal bacterial adherence. This study aimed to quantify and characterize mucosa-associated and intramucosal bacteria, particularly Escherichia coli, in these conditions. METHODS: Mucosa-associated bacteria were isolated, after dithiothreitol mucolysis, from biopsy samples obtained at colonoscopy (Crohn's disease, n = 14 patients; ulcerative colitis, n = 21; noninflamed controls, n = 24) and at surgical resection (colon cancer, n = 21). Intramucosal bacteria were grown after gentamicin treatment followed by hypotonic lysis. RESULTS: Mucosa-associated and intramucosal bacteria were cultured more commonly in Crohn's disease (79%, P = 0.03; and 71%, P < 0.01, respectively), but not ulcerative colitis (38% and 48%), than in noninflamed controls (42% and 29%) and were commonly cultured from colon cancers (71% and 57%). Mucosa-associated E. coli, which accounted for 53% of isolates, were more common in Crohn's disease (6/14; 43%) than in noninflamed controls (4/24, 17%), as also were intramucosal E. coli: Crohn's disease, 29%; controls, 9%. E. coli expressed hemagglutinins in 39% of Crohn's cases and 38% of cancers but only 4% of controls, and this correlated (P = 0.01) with adherence to the I407 and HT29 cell lines. Invasion was cell-line dependent. E. coli, including nonadherent isolates, induced interleukin-8 release from the cell lines. E. coli adhesins showed no blood group specificity, excepting 1 cancer isolate (HM44) with specificity for the Thomsen-Friedenreich antigen, but they could be blocked by soluble plantain fiber. CONCLUSIONS: These studies support a central role for mucosally adherent bacteria in the pathogenesis of Crohn's disease and colon cancer. Soluble plant fibers that inhibit their adherence have therapeutic potential.

 

[Brando]

http://iai.asm.org/cgi/content/full/73/8/5183

might be worth looking at if you can decipher scientific study jargon and it might help explain why probiotics tend to help some people with Crohn's. last paragraph is related to us directly.

too long didn't read version is that Lactobacillus, Bifidum, L. casei probiotics compete with E. Coli by binding to the receptor sites on epithelial cells (place where invasive E. Coli grows) and doesn't let the E. Coli back onto the cells to grow so it's basically a competition for which can bind to the receptor first. They also help by producing lactic acid which creates an environment unsuitable for E. Coli by fluctuating the pH balance in the intestinal tract and also by stimulating the immune response to E. Coli in general.

although it is highly experimental chlorine dioxide -> sodium chlorite treatment has shown to be a highly effective chemical at killing a number of gram negative bacteria and other parasitic infections (used in the Anthrax attacks to kill the Anthrax spores and also used in disinfecting water, raw meat after and animal is killed, and in some toothpastes) and people are experimenting taking it in very small doses.. something like 1 ppm. use at your own risk though as exposure to high levels of it causes bronchitis, constant exposure can cause chronic bronchitis although the levels are much more than 1 ppm.