How long does Humira take to work?

[hannah-rose]

When I took Remicade results were almost instant, but with Humira (two loading doses and one normal dose) I don't feel a lot of improvement.

I read it can take up to 6 months to feel the full effect, is that true?

 

[Emily]

I would say it took me about a month to notice it helping. Maybe around the second 1-injection dosage. I hope it works for you, and soon!

 

[littlemissh]

About a month for me too.

 

[Amanda D]

It has been 7 weeks since I took my first dose of four shots and unfortunately I don't have any changes to report yet. I am being patient though, it has got to work sometime!

 

[Jimena]

For me, it takes six months to feel the full effect. :redface: Now i have been using it since 2007.

 

[hannah-rose]

Thanks guys! Got an appointment with my GI in a couple of weeks, it just doesn't seem to be as good as Infliximab, which is a shame

 

[oathy]

So glad I found this thread.
I was going to ask the same.Ive been on humira since april I never had a loading dose for some reason.

Im on 40mgs every two weeks.Ive had another bad GI bleed again today.My doctors in london are amazing they mentioned something about another 7 weeks do you think that might make a difference? or is it looking like humira isnt working.they have also noticed my BP has gone through the roof just like when I took infliximab it seems to drop near the end of the 2 week cycle then few days after the injection its going to like 143/121 im on 2 lots of Meds for the BP now.

 

[oathy]

Thanks guys! Got an appointment with my GI in a couple of weeks, it just doesn't seem to be as good as Infliximab, which is a shame

I was telling my mum the same thing earlier.

 

[hannah-rose]

I was telling my mum the same thing earlier.

Which Hospital do you go to in London? Im living there at the moment but I'm moving to Bedford in a couple of weeks, my Doctor's based there.

I don't really understand how one 'mab' drug can work better than another - surely they all block TNFs so why did Inflix work instantly and also worked amazingly well, where as Humira is sort've maybe helping but the same time I started Humira I also had a major reduction in my stress levels so I'm wondering if that could have played a part too. There are other anti-TNF drugs available now, I want to talk to my doctor about those on my next visit.

 

[oathy]

Which Hospital do you go to in London? Im living there at the moment but I'm moving to Bedford in a couple of weeks, my Doctor's based there.

I don't really understand how one 'mab' drug can work better than another - surely they all block TNFs so why did Inflix work instantly and also worked amazingly well, where as Humira is sort've maybe helping but the same time I started Humira I also had a major reduction in my stress levels so I'm wondering if that could have played a part too. There are other anti-TNF drugs available now, I want to talk to my doctor about those on my next visit.

my main hospital is Central Middlesex.But also attend St marys.hammersmith (at times)

I truly understand how you feel.On infliximab I didnt bleed once im now on my 3rd bleed in less than 6 weeks.I had been told how much easier but would work the same humira would be but im back on steriods like crazy now.

I also Take Thalidomide which has anti TNF but the dangerous nature of the drug doesnt make it one of choice and even that doesnt seem to be working with Humira like it did with inflixmab.Was there a bad reaction to the inflixmab? with me once they started removing the growths off my face they were 100% sure it caused it and they stopped it straight away.

 

[Scaryman]

Did any of you guys have diarrhea after taking your first loading dose?

 

[oathy]

Did any of you guys have diarrhea after taking your first loading dose?

Yes.
Still getting it after the injection (about 4/5 hours) seems to settle down by the following day.*Im due to cease the drug early next year it just hasnt worked for me

 

[Scaryman]

Yes.
Still getting it after the injection (about 4/5 hours) seems to settle down by the following day.*Im due to cease the drug early next year it just hasnt worked for me

If you don't mind me asking what kind of problems are you having, why are they discontinuing early next year? Can you give me more specifics?

 

[oathy]

If you don't mind me asking what kind of problems are you having, why are they discontinuing early next year? Can you give me more specifics?

hi

Still bleeding when im trying to cut down the steriods.
Getting a lot more attacks of pain than I did on Inflixmab
basically im taking the jab and still having to rely on the steriods something the doctors are trying to avoid because the steriods really starting to affect me now.

totally gutted the GI bleeding is still present about 4/5 weeks after cutting down steriods.depending on the bleed I raise the steriods and it settles down again after about 2 weeks.

I know its only me personally and totally respect it does work really well for others I would give infliximab 8/10
and Humira about 4/10

 

[Scaryman]

So you get humira 8 to 10 weeks? What was your prednisone tapering from and what were you at when we started having the bleeding?

 

[Sashawright]

Scaryman, I also had diarrhea after my loading dose, seems to have eased up. I also had bad cramps in my calves for 2 days which have since gone away.

 

[Scaryman]

Scaryman, I also had diarrhea after my loading dose, seems to have eased up. I also had bad cramps in my calves for 2 days which have since gone away.

Keep in mind I did ask my doctor about this. He said that it could be from my strictures opening up. Even though I pointed out to him that it's one of the side effects of Humira. Not sure what to make of it but the diarrhea has eased up just a lot of noise in my bowel which is okay.

 

[oathy]

So you get humira 8 to 10 weeks? What was your prednisone tapering from and what were you at when we started having the bleeding?

hi.
im on 40mg every two weeks.
i started it around late April pred has been hovering around the 100/120mg for the past 18 months.Things go downhill quite fast when i hit around the 50mg its sub 45mg about 3 weeks on that dose the bleeding begins again.
So at the moment im just on 60mg of pred 150mg of thalidomide and 40 mg of humira

 

[Scaryman]

Oh okay, as I said about Crohn's this is such individualize disease in my situation if I can't taper off Prenda zone while on Himara methotrexate combination then I might need surgery. At least that's what the GIs in the University of Chicago said.

 

[oathy]

Oh okay, as I said about Crohn's this is such individualize disease in my situation if I can't taper off Prenda zone while on Himara methotrexate combination then I might need surgery. At least that's what the GIs in the University of Chicago said.

Yes
In my brothers case he had to have some of the small bowel removed
but they decided to keep him on infliximab

 

[Scaryman]

Ok I just want to clear that up in my head. Thanks again.

 

[newlymarriedtocrohns]

Hubby tried Humira a year ago for about two - three months, but it didn't really have any effect. Now he's on it again with methotrexate. Thanks for the tip that he might have to wait several months to see any result. He might not have waited long enough the first time for it to kick in.

 

[The Cursed]

Hey guys, how are you doing. Any follow up info?..

I'm to start humira this week. I'm currently on apriso, 6mp, and some form of dose of pred, currently 15 mg and have been bleeding, with poor quality poop for about a month straight now. As you well know this throws a wrench into life pretty good.I really hope the humira kicks this thing in the butt (pun intended)ANY feedback is greatly appreciated. I'm so frusterated.

 

[F.u.Crohns]

Oh okay, as I said about Crohn's this is such individualize disease in my situation if I can't taper off Prenda zone while on Himara methotrexate combination then I might need surgery. At least that's what the GIs in the University of Chicago said.

really? I haven't been able to tapper off prednisone either and i Been on humira for a while. It isn't working for me but I figure i might need surgery now since i feel my termin. illue. is always sore.