Fissure2--I just read some of your other posts. Your fissure sounds bad. If it were just a simple fissure, biologics wouldn't be needed, but since you had a bad report from your sigmoidoscopy, your doctor must see that you need strong meds to help more than just your fissure. Don't panic. All of this is new to you, but there are many folks on this forum that can relate to what you are going through and can help you through this.