My son had this a few times early on. Are you using epipen or syringe? Humira has on-call nurses for questions, they know the meds and typical reactions better than GI does. It's probably fine as long as it goes away in a few minutes, takes a little time for the body to absorb it. Be sure you've got a good pinch and 45 degree angle. We ice up beforehand and cover with a blanket after to warm up. I wouldn't massage it.