Immune Response To Bacterial Infection May Have Shaped Genetics Of Inflammatory Bowel

[Igor_Passau]

......
The team found that 70 per cent of the genetic regions associated with IBD are shared with other complex diseases, especially those also driven by abnormal inflammation, such as psoriasis and ankylosing spondylitis. They also observed a strong overlap between their IBD regions and genes underlying susceptibility to mycobacterial infections such as leprosy and tuberculosis, again highlighting the relationship between IBD risk and our immune response to bacteria.

....
http://www.medilexicon.com/medicalnews.php?newsid=252273

 

[SidS]

Pretty interesting read. If our immune system is over reactive then for me the only cure seems to be, stem cell as we replace our immune system with new ones. I am wondering if the cure lies with modifying our immune system. I remember reading a wiki article that says a cure for AIDS could mean a cure for Crohns since we need to trick or modify our immune system.

http://en.wikipedia.org/wiki/T_cell_vaccination

 

[wild_one353]

i actually developed ankylosing spondylitis when i consumed a bad batch of homemade yogurt. by lowering my intake of meat and taking antbacterial herbs i was able to eliminate all the symptoms, in about 2 months. it was absolutly painful.

from this observation i concluded that crohns may simply be an inability to eliminate any transient bacterial pathogens, so they create a chronic infection within the gut. these bacterial toxins from the infection may cause the malfunction in different places of the body, or even when the bacteria manages to translocate through the intestinal wall, and establishing themselves in a particular area of the body, in this case, the spinal vertebrae. Klebsiella pneumoniae in the feces has been found to be associated with AS

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1001180/


from my research, a better way to describe what happens to the immune system in crohn's is that it is ineffective at eliminating certain pathogens, im not sure there is enough information to warrant a description that it is overactive. underactive may be a more appropriate description.

 

[SidS]

i actually developed ankylosing spondylitis when i consumed a bad batch of homemade yogurt. by lowering my intake of meat and taking antbacterial herbs i was able to eliminate all the symptoms, in about 2 months. it was absolutly painful.

from this observation i concluded that crohns may simply be an inability to eliminate any transient bacterial pathogens, so they create a chronic infection within the gut. these bacterial toxins from the infection may cause the malfunction in different places of the body, or even when the bacteria manages to translocate through the intestinal wall, and establishing themselves in a particular area of the body, in this case, the spinal vertebrae. Klebsiella pneumoniae in the feces has been found to be associated with AS

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1001180/


from my research, a better way to describe what happens to the immune system in crohn's is that it is ineffective at eliminating certain pathogens, im not sure there is enough information to warrant a description that it is overactive. underactive may be a more appropriate description.

Intersting enough in wikipedia it says some researchers believe that it crohns might be the cause of being underactive.