Increased cancer risk?

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There is a lot conflicting, confusing and misleading info on the net so I was wondering if anyone could shed some light?

I accept that CD sufferers have an elevated chance of developing cancer but my question is this, as a CD sufferer who is having regular check ups surely I would have a better chance of early diagnosis and cure than someone who never has checks? I hear it can take 10 years to develope so its always going to be caught early if you're having regular checks is it not?

Are there any stats on this?
 
I do not know if there is any studies on this since there are so many variables involved.

Cancer is much easier to prevent than it is to get rid of. New Canadian study shows that vitamin D is a potent anticancer vitamin. This is not really news to many people but it does confirm the theory and hopefully more studies are forth coming.

http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20070607/vitamin_cancer_070607

I tend to trust Canadian studies much more than U.S. studies as I do not think the Pharmaceutical industry has as much control over the studies as they do in the U.S. It is hard to explain why it took this long to have a simple vitamin D study in disease prevention except that it was not in someones best interest.

Since much vitamin D is produced by sun exposure though the skin, sunscreen should only be used for long exposure to direct sunlight..

Antioxidants are another good preventative measure. Green Tea, Grape seed extract, Turmeric, Ginger, blueberries, and several other fruits are good antioxidants.

Since I smoke and am trying to "have my cake and eat it too". I consume lots of high antioxident food to reduce my risk.

D Bergy
 
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Crohn's Diease is fairly well established as a risk factor in small bowel cancer. Fortunately. small bowel cancer is very rare even with the increased risk in Crohn's cases. I wouldn't lose too much sleep worrying about small bowel cancer.

The evidence for CD or UC as a risk factor in colorectal cancer is much more controversial as is the use of surveillance conoloscopy in IBD cases. Here's a fairly recent study from Denmark
http://www.springerlink.com/content/h84708u17k840200/
Crohn's disease and cancer risk (Denmark)
Lene Mellemkjær1 , Christoffer Johansen1 , Gloria Gridley2, Martha S. Linet2, Susanne Krüger Kjær1 and Jørgen H. Olsen1

(1) Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100 Copenhagen Ø, Denmark
(2) Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Mayland, USA


Abstract Objectives: The large number of studies of intestinal cancer among patients with Crohn's disease have provided inconsistent risk estimates in regard to risk of both colorectal and small intestinal cancer. We investigated incidence of cancer among Crohn's disease patients in comparison with the incidence in the general population of Denmark.
Methods: From the Danish National Registry of Patients we identified 2645 patients who had been hospitalized with Crohn's disease during 1977–1989. Cancer incidence for up to 17 years was determined in the cohort and compared to an expected number derived from national cancer incidence rates.
Results: The 15 observed cases of colorectal cancer were close to the expected number of 13.1 (SIR = 1.1; 95% CI 0.6–1.9), whereas the five cases of small intestinal cancer (three adenocarcinomas and two carcinoids) observed corresponded to an 18-fold increased risk (SIR = 17.9; 95% CI 5.8–42).
Conclusions: A potential excess of colorectal cancer among subgroups of patients with Crohn's disease was not detectable in the overall risk estimate for colorectal cancer. Only for small intestinal cancer was a significantly elevated risk found among these patients hospitalized with Crohn's disease.
cohort studies - Crohn's disease - inflammatory bowel diseases - intestinal neoplasms - risk
 
Increased risk... I dunno of any stats, per se, but the obvious reasons are that a lot of the areas (assuming one of the cancers in question is colo-rectal) giving increased risk are enflamed... so finding something in a healthy colon would be easier than in a colon pockmarked from the disease. and a lot of the warning signs would be masked by the symptoms... I mean, I for one wouldn't hit the panic button at the sign of any blood in my stool... but a healthy person w/o IBD? All the alarms bells would be going off.. (or at least should).. And, if you have IBD, then a lot of the drugs you may be taking have an elevated risk factor by default. I just started imuran... and now have to wear an SPF sunscreen of at least #35 as a precaution... else my elevated chance of skin cancer places me in a 'high risk' category. So, all in all, with the masking of symptoms, and the fact that we all tend to focus on just what's in front of us (like, I mean, IBD affects me daily, rarely do I stop to consider 'cancer'.. despite the fact that I've been told my risk is higher than it was pre-IBD.. do I really want to put that on my plate to digest daily also?)
and then factor in all of those nices meds that give increased risk YET AT THE SAME TIME lower our immuno responses... and then you start to get the 'big picture'..
As for how long it takes to develop, spread... Well, again, in a 'healthy' system, it's a lenghty process. I can't recall how many cases Iv'e heard of where it was caught before it got thru the wall of the digestive system to where it could really take off. But, in a compromised intestinal system.. with deep scarring from ulcers, or a path cut by a fistula, or a fissure, or just from years of the disease eating away at the tissue, or the lack of the protective mucuous, then the timeline is probably far less.
I dunno. I'm not a doctor, much less an GI or oncologist. But it seems to be logical that any chronic, long term illness, esp one of the IBD's, and the risk of cancer, and espically colo-rectal, is going to be increased. That's just the hand we are dealt.

Is it all bad news? No, I don't think so. First off, we deal with doctors frequently, and they should be aware of all of the risks, and they should be watching for this.. We have to do our share.. watch for signs, note any changes, report them if we do
And, we have all of those lovely tests.. OK, so maybe it is easier to see a 'tumour' in a healthy colon via colonoscopy, but how many healthy people have them done?
and there is the bloodwork, the X-rays, the ultrasounds, the CT and MRI scans.. In the past 3 years, I have been examined, cut into, poked around in, up & sideways more times than I can count.. Surely, if anything else was going on, someone in the group grope would have seen something.. In any event, I don't recall being told that IBD is a 'killer', just the opposite, and altho overall my risk of cancer is a lot higher now, I don't get the impression from my doctors that if the IBD doesn't get me that cancer will. or that associated cancer is the kill factor for one with IBD

That's just my take on the subject... Think perhaps you were hoping (or clutching) for a more positive response.. Sorry if I dissappointed.. But I think that what will be, will be. Don't get me wrong.. I'm totally into the 'ounce of prevention' method, but I also think that waiting for the proverbial 'cancer' shoe to drop isn't the best way to pass ones time when you already have a disease that seems to thrive on stress. Like, don't go feeding the devil you know while waiting for another who may never show up. That's a common sense approach I learned from my mom, a cancer survivor who was supposed to die from it 45 years ago, but just wouldn't...
 
From what I've read it's 0.5% increase every year after 10 years of IBD, not a lot but significant enough to keep an eye on it, but I was getting at the fact that an IBD sufferer is far more likely to get this caught and treated early than an average person with no known health issues.
 
Those are actually comforting numbers... just wonder if they relate to just disease itself, or compound with added risk from meds. Like, for example, the stat sheets I got with my imuran give me the numbers (%) for risk of side effects of almost all of them (indigestion, nausea, allergic reaction, bone marrow suppression, pancreatitis, etc..) and they range from 1% - 2.3% (+/-)... But, when it comes to the 'cancers' that this drug mayincrease your risk of, like lymphoma or leukemia, they don't provide any numbers... just state that long term treatment, medication is known to 'slightly' increase the risk. Wish they'd have put a number on those..
 
Kev said:
But, when it comes to the 'cancers' that this drug mayincrease your risk of, like lymphoma or leukemia, they don't provide any numbers... just state that long term treatment, medication is known to 'slightly' increase the risk. Wish they'd have put a number on those..

I don't think anyone really knows the numbers. There is some indication from studies that the risk doesn't really increase at all for the relatively small amounts we take.
 
these drugs havent been out long enough to truly categorize its longterm side effects in my opinion. thats prob why they can't even give numbers
 
Heres something I cut & pasted from a pdf outline of Imuran from the manufacturer..

"The incidence of lymphoproliferative disease in patients with RA appears to be significantly higher than that in the general population. In one completed study, the rate of lymphoproliferative disease in RA patients receiving higher
than recommended doses of azathioprine (5 mg/kg/day) was 1.8 cases per 1000 patient years of follow-up, compared with 0.8 cases per 1000 patient years of follow-up in those not receiving azathioprine. However, the proportion of the
increased risk attributable to the azathioprine dosage or to other therapies (i.e., alkylating agents) received by patients treated with azathioprine cannot be determined."

In another area,they noted that there were too few clinical trials to cover people aged 65+ or under 18.. don't know how many crohnies are over 65, but there seems to be a lot under 18

anyway, got the info from the glaxosmithkline website... i'm still in the midst of reading thru and processing the double talk legal speak its worded in.. you know, where the R & D guys report something, then 'legal' takes it and clarifies it until you don't know what they're saying..
 
The risk for colon cancer is slightly higher for those with CD affecting their colon (crohns-colitis) which is what I have and have had for the entire 16yrs of having CD and I still don't have colon cancer, so nothing's written in stone since they estimate that if you've had inflammation in your colon for 10 or more yrs your risk for colon cancer increases that much more...UCers tend to have a slightly higher risk for colon cancer simply because their inflammation is restricted to the colon and sometimes involves the rectom...as with CD it can affect the entire GI tract from the mouth to the anus, and the majority of CDers don't typically have crohns-colitis....CD affecting their colon, CD mostly likes to hang out in the small intestines.

:)
 
My cousin is a health food nut. He told me once that " I can be healthy as a horse and not worry about any disease and still get hit by a Twinkie truck."

I think that is a good way to look at it, sort of.

D Bergy
 
Yes. Its' a great way to look at it. Being a health nut doesnt' guarrantee you life, and having IBD doesn't mean you'll die from colon cancer... there are no guarrantees
 

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