I think it depends on how the body responds to the medication. Some may be more reactive to the ingredients in the medication than others. I doubt the Entyvio is increasing your inflammation, but have you gotten your blood work done lately to see?
Some of my blood markers have improved a bit, but I have literally read a couple of hundred posts on this forum and Drugs.Com plus Entyvio's website and have experienced "before and after" infusion symptoms:
Its fairly common for people to have severe diarrhea, cramps, on and off fever and chills, severe fatigue, brain fog, visual problems and many more post-infusion symptoms.
I did not have all of these symptoms before the Entyvio and I've kept close track of my health since my third Crohn's colitis flareup was diagnosed about seven-months ago (I had the symptoms months before the diagnosis).
If any drug or other healing modality causes far more harm than good, then its part of the problem.
Getting three loading infusions of Entyvio was my fault for giving into the oblique "what if my health" threats to the bloated, brainwashed nurse practicioner and my GI doctor. I was so concerned with trying to get better and avoid possible future surgery(ies) that I did not read up on enough on the possible side-effects of Entyvio such as PML, cancer, liver problems and so much more.
One of many "elephants in the room" is the fact that nutrition and stress 100% can help or worsen IBS and IBD. "Just" dairy, wheat, nuts, seeds and raw produce alone can worsen GI symptoms alone.
Then there is the overprescription of anti-biotics which contribute to leaky gut which worsens IBS and IBD.
And my GI doctor and his NP who've been doing this for DECADES told me (and all other patients with anemia) to take oral Iron (for my anemia) which often WORSENS the symptoms of IBS and IBD.
I am not a doctor, but doctors have zero excuse to have a closed mind when it comes to someone's quality of life.