Hi everyone: After trying prednisone and being on Imuran for the past three months with no change to my Crohn's, I finally started Humira today. I had my 4 loading injections today. The nurse did the first two and I did the second two. I almost passed out after the second injection--felt very light headed and nauseous. The nurse told me that was a common occurrence. I laid down for a bit and she suggested perhaps I go home and do the other two myself later in the day at home, but I was determined to have it all done this morning. Waited until I was feeling much better (about 30 minutes) and then did the last two myself. It was actually less painful when I did it myself and had no reaction at all. I have a bit of a hive where the first injection went in but not at the other three at all. I was so apprehensive about the shots in the first place I'm just really glad I got them all done today! Now I will just wait and see if this will start to help me in the next couple of months!