Well, since i'm a go big or go home kinda gal, i started with 3 pills 3x daily. Until four days ago. I developed really itchy, puffy skin on the backs of my hands and since I know the glutamine is the only thing new I backed off to two per day, hands went back to normal. Yipee. I can eat sugar without itching or pain, yeast issues are diminished, and as for anything else I guess I will have to wait for blood work to see any changes. I'm really happy about the sugar thing - I Love chocolate and even the 60% has sugar.