Microbiome Research Transforming the Field of IBD -- CCFA

[Crohn2357]

Microbiome Research Transforming the Field of IBD
http://www.ccfa.org/research/current-research-studies/microbiome-video.html

 

[kiny]

"probiotics with proven results"

I would argue probiotics have a disappointing record in IBD. Manipulating the microbiome isn't going to stop intracellular bacteria like AIEC. If anything probiotics might make people sicker. I've never read that they could induce remission with probiotics, let alone cure.

45 patients on probiotics, no benefit whatsoever:
http://www.ncbi.nlm.nih.gov/pubmed/12408444

165 patients on probiotics, no benefit whatsoever:
http://www.ncbi.nlm.nih.gov/pubmed/23466709

If anything would help CD, it would be those 2, lactobacillus who find their place in the ileum and S. Boullardi which produces SCFA, and they don't help at all.

 

[wild_one353]

very nice.

Even though this is a very casual collection of statements, they claim that family members of IBD have a similar intestinal microbiome. In a recent report where a man achieved complete remission with a fecal transplant he achieved this using his 10 year old daughter as the donor. This contradicts the theory that using a family member with supposedly a very similar microbiome would NOT have a beneficial effect on a patient.

Even though this isnt exactly a scientific publication, I would like to see how exactly they concluded that many family members of ibd patients all have a similar microbiota. I have a feeling that although it may be commonly found that IBD family members seem to have similar microbiomes, it is not determined by genetic heritage.

 

[Crohn2357]

Tagging Old Mike.

 

[Crohn2357]

kiny, interesting:
Short communication: progression of Johne's disease curtailed by a probiotic.
http://www.ncbi.nlm.nih.gov/pubmed/19762800

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http://www.depts.ttu.edu/iacuc/docs/Brashears.php

 

[JMC]

I look forward to this producing something specific that can really help IBD patients. In the meantime, CCFA can fund the research for years and years...

 

[mf15]

No question they should be doing it,may also lead to a better understanding of the
correct donor to supply a FT.
Also suggest they start from the top down,oral bacteria and its dysbiosis.
Especially our entero salivary nitrate nitrite NO pathway,for a possible lowered amount of
nitrate reducing bacteria,or reduced metabolism. As compared to non western people. Also how a high nitrate/nitrite diet might improve IBD.
They do find oral pathogens in the colon,and they should not be there.
They find dysbiosis in early onset crohn's, exogenous NO is our first line
defense,nitrite in saliva is swallowed,turns into NO in the stomach,if this is
inadequate bacteria killing will be impaired.
Old Mike

 

[Crohn2357]

http://omicsonline.org/a-potential-...f-bovine-johnes-disease-2161-1068.1000117.pdf