Has your doctor given you any statistics on this? How likely is it with 150 polyps that one will become cancerous?
Because I think the most important part of this decision is the risk of developing bowel cancer. And also how well you as an individual feel you will cope with that risk. Some people will greatly prefer to reduce that risk with surgery and for others, depending on personality and circumstances, that may not feel as important.
It's sounds like a real positive that this part of your colon is the only area of active disease in your bowel. For some people, depending on how long they've tried to get rid of that active disease with various meds, that would be reason enough to have a resection. And you have the additional benefit of getting rid of all those polyps.
If you want to have the surgery for the polyps anyway then there is not necessarily any benefit to waiting and giving the meds time to work on the Crohn's.
If you feel that on balance you do not want to have surgery for the polyps then you could give the meds more time to work. How are your Crohn's symptoms affecting you? And how long have you been trying to treat this active disease without success?
Other than those thoughts, my advice would be that surgery is often not as terrible as we think it will be. It's completely natural to have a resistance to surgery but sometimes it is the best option. There are things like polyps, or in my case strictures, that meds just can't treat.
