New IBD drug..have u heard of it?

[Fosterfamily2303]

My doc wants me to try a medication like remicade. Vedolizumab. Have you heard of this or no anyone who has taken it? From what I gather it's given just like remicade (including a loading dose). My gi is a little concerned as I developed drug induced lupus from remicade but feel like she is stumped .

 

[7vNH]

Remicade and Humira are monoclonal antibodies that target TNF-alpha. Remicade's source is chimeric (not from a human), whereas Humira's source is human. The GI probably knows that Humira is worth skipping (maybe thinks that anything that targets TNF-alpha would trigger lupus again?). Remicade has 0.6% adverse reports of lupus like syndrome, whereas Humira has 0.07% adverse reports of lupus like syndrome (this, according to druginformer.com). Cizma (aka certolizuman pegol) also targets TNF-alpha, but is a fragment, not a full antibody (no report on druginformer).

Entyvio (aka vedolizuman) is also a monoclonal antibody, but it targets integrin alpha4 beta7 (not TNF-alpha). The source is not human, but has been 'humanized' (no report on druginformer.com).

 

[Fosterfamily2303]

Thank u. I never heard of it..and didn't see anything on here about it.

 

[tzvia]

There are several threads in here about Entyvio.

 

[SupportiveMom]

Another option is Simponi (golimumab) if entyvio doesn't work for you. Maybe 7vNH can explain how simponi works. We are just starting it tonight and I am already confused why docs pick one drug over the other. My kid is getting it off label as it is not yet approved for crohns or for kids.

 

[Fosterfamily2303]

I have unfortunately tried EVERYTHING but this . My doc don't think K surgery is right as she believes I will continue to have problems.