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http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039242
New type of Ibd test for those undiagnoised
New type of Ibd test for those undiagnoised
New Ibd test
- Thread starter my little penguin
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From what I can tell they still just look at stool ( fecalopectin)by look for different things and can tell if the kiddo has cd or UC an would need a cOlonscopy .
On the phone so ignore typos.
On the phone so ignore typos.
DustyKat
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Mlp is thinking along the same lines as me. 
Faecal Calprotectin and the like were the beginning of tests that the medical profession hoped would reduce the need for more invasive tests when it came to establishing the inflammation present in the bowel and also a persons response to treatment. The idea being that for children this type of testing would be far preferable.
This new test is again using faeces and so is designed to be non invasive but since RNA (more or less a building block like DNA) is involved I imagine it has the ability to differentiate between UC and CD based on the characteristics that are seen microscopically.
Of course I may well be talking through my ass and a dumb one at that! :lol:
Dusty. xxx
Faecal Calprotectin and the like were the beginning of tests that the medical profession hoped would reduce the need for more invasive tests when it came to establishing the inflammation present in the bowel and also a persons response to treatment. The idea being that for children this type of testing would be far preferable.
This new test is again using faeces and so is designed to be non invasive but since RNA (more or less a building block like DNA) is involved I imagine it has the ability to differentiate between UC and CD based on the characteristics that are seen microscopically.
Of course I may well be talking through my ass and a dumb one at that! :lol:
Dusty. xxx
:rof: :rof: :rof: :rof: :rof:
A new test for poop that can detect active disease, distinguish between UC and CD and they had to call the thing ............... SLiME????
Sounds like a winner to me.
:award2::award2::award2::award2::award2:
A new test for poop that can detect active disease, distinguish between UC and CD and they had to call the thing ............... SLiME????
Sounds like a winner to me.
:award2::award2::award2::award2::award2:
Ok, so if I am reading this article correctly (I sure hope somebody who has some microbiology training never reads this cause they will probably laugh their socks off) these really, really smart guys at Children's Hospital in Boston used DNA sequencing to identify classes of microbes in poop. They figured out which microbes were there (microbial classes), how much there was of the different kinds of microbes, how those two things changed with disease status, etc. and confirmed their results with an independent blind testing of a separate cohort of kids.
This is really cool stuff and sounds like it could be the Holy Grail for non-invasive testing. Goes waaaaay beyond the information you can get from fecal calprotectin testing.
Their work is based on previous work by someone else (FRank) that did a similar thing with tissue samples. The results from poop were very, very similar to the results they got using tissues.
SLiME (actually a very complex set of algorithms used to assess DNA sequencing results) was reliably able to distinguish:
1. Active vs. remission status in both CD and UC patients
2. Severity of disease activity
3. IBD vs Non-IBD kids
4. UC vs. CD
5. validates the effect of antiobiotics on gut microbes (kills em which is what happens when there's a severe disease flare, DUH)
This is definitely on my agenda for our next Ped GI visit.
This is really cool stuff and sounds like it could be the Holy Grail for non-invasive testing. Goes waaaaay beyond the information you can get from fecal calprotectin testing.
Their work is based on previous work by someone else (FRank) that did a similar thing with tissue samples. The results from poop were very, very similar to the results they got using tissues.
SLiME (actually a very complex set of algorithms used to assess DNA sequencing results) was reliably able to distinguish:
1. Active vs. remission status in both CD and UC patients
2. Severity of disease activity
3. IBD vs Non-IBD kids
4. UC vs. CD
5. validates the effect of antiobiotics on gut microbes (kills em which is what happens when there's a severe disease flare, DUH)
This is definitely on my agenda for our next Ped GI visit.
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