I am a 41 yr old female. Diagnosed with Crohn's disease back in 1987. I have had two ressections. I have tried many medications that work for a time but end up not working or side effects are too bad I must stop. This past year I have new challenges....my iron, ferritin and hemoglobin were so low I need a blood transfusion. Now I am taking Venofer infusions every three months to stabilize my blood. I also need to make a decision of starting Imuran or Methotrexate. Any feedback on these drugs would be much appreciated. So my question is two fold....anyone else suffer with severe anemia and what drug should I choose to try first?