Nod2 mediates host resistance to MAP infection

[kiny]

http://www.paratuberculosis.info/web/images/proc11/108.pdf

"In summary, disruption of NOD2 was associated with diminished killing of MAP by macrophages, reduced innate and adaptive immunity in the host and impaired immune responses required for control of intracellular mycobacterial infection."

It's short to read, so you might as well click the link.

 

[kiny]

Any doctor who still denies that there are links between MAP and Crohn has a whole lot of explaining to do.

*We know MAP is found more in crohn patients than in controls. (too many links)
*We know Infliximab kills MAP. http://www.ncbi.nlm.nih.gov/pubmed/22398081
*We know Crohn patients are more likely to have defective Nod2 and we now know defective Nod2 makes those people more susceptible to MAP infection. (this study)
*We know Vitamin D and especially Vitamin A are primary mediators for MAP. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250462/?tool=pubmed

 

[David]

Thanks for the link Kiny. MAP may play a role, but everything you stated you could insert a variety of different bacteria and it probably be true.

- A variety of bacteria are shown in different numbers in Crohn's Patients and we must remember that many types of intestinal flora can't even be cultured and are still being discovered.

- We have a great wiki entry on Nod2 - probably the best collated data for Crohn's Disease and NOD2 on the net. Give it a read: http://www.crohnsforum.com/wiki/Nod2-Card15-Gene

- Vitamin D and A mediate the immune system so of course they'll play a role in mediating MAP along with just about every other potential pathogen.

It would be easy to convince me that MAP plays a role in some people with Crohn's Disease. But that's about it at present.

 

[kiny]

They're starting to use nano sensors on blood, it decreases the costly PCR method and it's much more accurate, hopefully they can start doing this for crohn patients.

The only other pathogen that I have seen evidence of that is more seen in crohn patiens is E. Coli, but E. Coli doesn't really explain those macro shots they see from Johne's disease that are super similar to the ones from croh patients.

In one video you can find online they ask the audience if they can spot the difference between the intestins of a cow with johne's disease and a human with crohns disease, and no one in the audience who could tell the difference.