Pretty much the only problem is the Benadryl. If they put you on that, you probably should take the day off just as a precaution. It used to make me exhausted for the entire day, but everyone takes to it differently. The first day you do it, you should definately take off and then see how you do the rest of the day. If you feel normal then it's up to you if you want to take the day off. Like I said before, I would advise taking the day off anyway primarily because you're taking care of children and if you get home and have a bad reaction or get sleepy you have to worry about the children as well.
Good luck!