Who may need extra vitamin E to prevent a deficiency?
Individuals who cannot absorb fat require a vitamin E supplement because some dietary fat is needed for the absorption of vitamin E from the gastrointestinal tract. Intestinal disorders that often result in malabsorption of vitamin E and may require vitamin E supplementation include [3]:
* Crohn's Disease is an inflammatory bowel disease that affects the small intestines. People with Crohn's disease often experience diarrhea and nutrient malabsorption.
People who cannot absorb fat often pass greasy stools or have chronic diarrhea. People with an inability to secrete bile, a substance that helps fat digestion, may need a special water-soluble form of vitamin E.
What is the health risk of too much vitamin E?
Most studies of the safety of vitamin E supplementation have lasted for several months or less, so there is little evidence for the long-term safety of vitamin E supplementation.
ODS is working on updating this section of the vitamin E fact sheet to include the results of meta-analyses and clinical trials that have been published recently. A new version will be posted shortly.
The Food and Nutrition Board of the Institute of Medicine has set an upper tolerable intake level (UL) for vitamin E at 1,000 mg (1,500 IU) for any form of supplementary alpha-tocopherol per day. Based for the most part on the result of animal studies, the Board decided that because vitamin E can act as an anticoagulant and may increase the risk of bleeding problems this UL is the highest dose unlikely to result in bleeding problems.
Table 4 lists the Tolerable Upper Intake Levels (UL) of vitamin E in mg ATE and IUs for children and adults (1 mg ATE vitamin E = 1.5 IU). A UL for vitamin E for infants up to 12 months of age has not been established.
http://dietary-supplements.info.nih.gov/factsheets/vitamine.asp#h7
Abstract
American Journal of Gastroenterology
Volume 98 Issue 2 Page 348 - February 2003
doi:10.1111/j.1572-0241.2003.07226.x
Volume 98 Issue 2
Antioxidant vitamin supplementation in Crohn's disease decreases oxidative stress: a randomized controlled trial
Elaheh Aghdassia, Barbara E. Wendlanda, A.Hillary Steinhartb, Stephen L. Wolmana, Khursheed Jeejeebhoyc, and Johane P. Allard, M.D., F.R.C.P.a, *
Objective We showed previously that patients with Crohn's disease (CD) had increased oxidative stress and lower antioxidant vitamins compared with healthy controls. This is despite inactive or mildly active disease and maintenance therapy. The aim of this study was to evaluate in these patients the effects of antioxidant vitamin supplementation on oxidative stress.
Methods This is a randomized controlled trial where stable but oxidatively stressed CD subjects (n = 57) were supplemented with vitamins E (800 IU) and C (1000 mg) or their placebo for 4 wk. Oxidative stress measured by breath pentane and ethane output, plasma lipid peroxides, and F2-isoprostane was assessed at baseline and at 4 wk. Disease activity was also monitored by measuring CD activity index and plasma orosomucoid.
Results During supplementation, plasma vitamin C and α-tocopherol increased and all indices of oxidative stress decreased significantly. Disease activity remained stable.
Conclusions In this population, vitamin E and C supplementation resulted in a significant reduction in oxidative stress. This suggests that patients with inactive or mildly active CD can be oxidatively stressed and have increased requirement in antioxidant vitamins.
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This article is cited by the following articles in Blackwell Synergy and CrossRef
• M.-T. Huang, G. Ghai, and C.-T. Ho. (2004) Inflammatory Process and Molecular Targets for Antiinflammatory Nutraceuticals. Comprehensive Reviews in Food Science and Food Safety 3:4, 127-139
Abstract Abstract and References Full Article PDF
• M. A. Gassull. (2004) The role of nutrition in the treatment of inflammatory bowel disease. Alimentary Pharmacology and Therapeutics 20:s4, 79-83
Abstract Abstract and References Full Text Article Full Article PDF
http://www.blackwell-synergy.com/links/doi/10.1111/j.1572-0241.2003.07226.x/abs/
I would say take 400 IU of a natural Vitamen E supplement that would the D-Alpha-Tocopheryl or D-Alpha-Tocopheryl-Acetate or Dry Vitamen E (D-Alpha Tocopheryl Succinate)... If you see DL-Alpha something then your getting artifical Vitamen E which will not stay in the body as long as natural Vitamen E....
Then as far as Vitamen C goes I recommend taking Timed Released Esterfied Vitamen C either in 500 mg or 1000mg tablets... I would probably go with the 500 mg...
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