Pain killers crohn's NSAID

[my little penguin]

Statistical modeling restricted to patients with Crohn's disease showed that NSAID use at least five times a month was associated with a relative risk of disease flare of 1.65 compared with Crohn's disease patients who used NSAIDs less frequently or not at all (95% CI 1.12-2.44).

Acetaminophen use also had an independent association with increased disease activity among patients with Crohn's disease (RR 1.72, 95% CI 1.11-2.68).

From:
http://www.medpagetoday.com/MeetingCoverage/ACG/42333

So basically if you need pain meds at all your at higher risk for a flare .

 

[Maya142]

Ugh we really need to find a combination of meds that works for M, so she can stop taking NSAIDs.

 

[7vNH]

When the entire IBD cohort was divided into groups with Crohn's disease or ulcerative colitis, neither NSAID use (including frequent use) nor acetaminophen use was associated with disease flare in patients with ulcerative colitis.

So if you "know" you have UC, you need not be spooked by NSAID or acetaminophen. I had been laying off of the naproxin and instead going for acetaminophen because I read somewhere that naproxin (and other NSAIDs) were hard on the lining of the gut. I never noticed any problems taking naproxin or aspirin, but did get upset stomach from ibuprofin.

 

[Tesscorm]

Nsaids scare me and I've drilled it into S to not use them (so far, he's been lucky in that he hasn't need more than tylenols). While impossible to prove, there's definitely been a question about S's regular use of advils for 3 or so months and then his crohns onset...

 

[Catherine]

NSAIDS make me sick. I don't let any of my children take them.

 

[GreenwichUK]

NSAIDs are bad news!

 

[SarahD]

This isn't saying the NSAID's are ok, just that Acetaminophen is equally as bad. A relative risk of 1.65 means that compared to those who use NSAIDs infrequently or not at all, there is a 65% increased risk of disease flare in those who use NSAIDs regularly. More or less the same result with Acetaminophen.

I didn't read the whole paper, but I wonder whether the results are confounded because those who tend to use painkillers and those who are in the most pain, and that pain could be associated with the patients IBD. If you're in the begining of a flare you may be more inclined to use pain killers, and hence it might seem that the pain killers are associated with (but not causal of) disease flare.