PH/Sunlight and immune function Neutrophils suppression and migration

[mf15]

Might as well try and get it all in one thread. Seems that neutrophils are a major

part of our problem. Simply removing them from the blood, or perhaps blood letting can put people into remission.

My neutrophils in routine blood test over the past 10 years are high out of range.

Not sure where this might go,but perhaps it might explain the alkaline diet and

why it helps some with UC. Also more on sunlight. I have UC but may apply to all forms of IBD.

Old Mike

http://www.jleukbio.org/content/69/4/522.full

http://ajcn.nutrition.org/content/76/6/1308.full.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC498851/pdf/jclinpath00177-0104.pdf



Sunlight seems to suppress,never saw this before/might explain some things with UC.

http://www.jleukbio.org/content/65/5/573.full.pdf

Removing neutrophils.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2274988/

Migration,garlic pills are a blood thinner,the only effect I saw from them is I bleed more.

http://www.ncbi.nlm.nih.gov/pubmed/11330220

http://www.ncbi.nlm.nih.gov/pubmed/20589735

resveratol,tried it in the past, no effect on me.

http://www.impactaging.com/papers/v2/n4/full/100143.html

http://www.nutraingredients.com/Res...d-benefit-from-resveratrol-says-Spanish-study

RESVERATOL FAKED DATA not sure if the fakes concerned UC or not.

http://www.cbsnews.com/8301-504763_...her-dr-dipak-k-das-published-fake-data-uconn/



LTB4 attracts neutrophils.The way to lower is low veggie oils and take fish oil.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383307/

GM CSF perhaps a key,this link wont work,not even sure what it was now.

http://download.springer.com/static...950_6f0d0ba14ebc0908b0c63d804173878b&ext=.pdf

Antihistamines work on others but not gmcsf

http://www.ncbi.nlm.nih.gov/pubmed/10772385

Vitamin C as a regulator,have taken up to 4 grams a day with no effects.

http://bloodjournal.hematologylibrary.org/content/99/9/3205.full.pdf

Vitamin D also involved.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC104378/

HYC can up regulate magnesium can down regulate. My Hyc is high.



http://dermatology.cdlib.org/147/review/neutrophils/aronson.html



B3 upregulates.

http://www.signaling-gateway.org/update/updates/200903/nri2521.html

Fish oil.

http://www.jleukbio.org/content/71/6/981.full.pdf



Steroid resistance,interesting,vitamin d connection.

http://130.88.242.202/medicine/Aspe...aspergillus-web/articlesoverflow/19482216.pdf



Bromelain is possible.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2269703/



Whey seems to stimulate,not sure if good or bad.

http://jn.nutrition.org/content/139/2/386.full.pdf+html

interesting

http://www.biomedcentral.com/content/pdf/1476-511X-10-235.pdf



does b12 make us worse,seems to be necessary to make neutraphils.

http://www.livestrong.com/article/541164-low-neutrophils-and-a-strict-vegetarian-diet/

http://pptu.lefora.com/2012/06/20/neutrophils-protozoa-and-nutrition/



Fermented whey,might be a key. click on look inside the book,you really need to read this.

http://link.springer.com/article/10.1007/s00011-009-7100-y?LI=true#

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1845142/

http://www.ncbi.nlm.nih.gov/pubmed/10532380

Opioid receptor protein fragments.

http://www.ncbi.nlm.nih.gov/pubmed/11242443

http://www.ncbi.nlm.nih.gov/pubmed/12769741

Magnesium and neutrophils. I would think that some of us might be low in mag intake. Seems like it might be very important.

http://www.ncbi.nlm.nih.gov/pubmed/11895162

http://www.ncbi.nlm.nih.gov/pubmed/9989243

The big list.

http://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=11895162

Sidebar.

http://www.ncbi.nlm.nih.gov/pubmed/22038065

Spinach and micro rna.
http://www.aicr.org/cancer-research..._5_2012/cru-spinach-cooked-meat-microRNA.html


Mag and bifido and digestive enzymes

http://jn.nutrition.org/content/140/3/509.long

Calcium/mag ratio changing in USA.

http://www.ncbi.nlm.nih.gov/pubmed/22364157

CRC inflammation.
http://www.ncbi.nlm.nih.gov/pubmed/23125223

 

[David]

Thanks Mike.

I really appreciate the research you do.

 

[mf15]

Thanks David: Have added a few more studies on magnesium,and neutrophils,TNF alpha ect.
Old Mike

 

[David]

Not sure if you saw my post before edit (I decided to remove it as I still have a lot of work to do on the subject) but I agree with you on the Magnesium. I'm starting to suspect that Mg deficiency is a HUGE part of the problem.

 

[LittleChloe]

Something interesting that i wanted to share but i didn't know if it was even significant. I've had Chloe on several mineral supplements in addition to Ldn. At her last follow up her bloodwork was perfect, no pain, no symptoms...nothing. So i decided that since she was obviously absorbing nutrients from food, that we could scale back. I started with magnesium. When the bottle ran out I just didn't get another. Well last week she had her first mini flare in MONTHS! It only lasted 2 days and it wasn't bad at all, she didnt even miss school. I know this is to be expected to some extent, but still i can't help but wonder whether its the crazy magnesium that's holding this all together?! Anyway she's going back on it. Thanks for all the information.

 

[David]

Julie, I think magnesium has MUCH MUCH more to do with IBD than is realized.

Frankly, I don't see how anyone on this forum who doesn't supplement isn't deficient in magnesium. Here are the foods highest in magnesium:

And here is the RDA based upon age and sex:

Source

Just on straight math, how many of you think you are getting enough magnesium?

From the Linus Pauling Institute:

A large U.S. national survey indicated that the average magnesium intake for men (about 320 mg/day) and the average intake for women (about 230 mg/day) were significantly below the current recommended dietary allowance.

 

[mf15]

Just watch yourself with magnesium, I took too pills over the RDA yesterday,I happen to have magnesium oxide and mag gluconate pills,well my urine pH shot up over 8 and my colon did not like the hi ph either. Not sure which magnesium salt is safest. You really do not want to go over the 350 or so mg, max dose of magnesium a day from all sources.
Mag chloride is a possible,little hard to find and it is hygroscopic.
Old Mike

 

[David]

Do you have any sort of renal impairment?

I'm taking 750mg of supplemental magnesium per day, split between morning and evening. I've been doing this for about a week now and feel AMAZING. I base it upon this article which suggest 600mg for a month and the fact that I'm bigger than most people.

So far I feel amazing but the current plan is to drop it down to 250mg per day at the one month mark and try to greatly increase my intake of Mg containing foods as I prefer to keep my non food-based vitamin/mineral intake to a minimum.

 

[Susan2]

The problem for me is that all the nuts, bran, lentils, peas, beans, brown rice etc. at the top of the list cause me trouble. Other than spinach (very finely shredded), oatmeal and peanut butter, on I am down to yoghurt, bananas and chocolate...

I take one 300mg capsule of a blend of different forms of magnesium per day. As I have said somewhere on the Forum before, if I stop taking the magnesium, I get restless legs back and that reminds me to start taking it again.

 

[David]

I think many share the same problem as you Susan. The problem is, telling them to get tested is a problem because the VAST majority of doctors (if they bothered to test) would test serum magnesium. And the body does everything it can to keep serum magnesium at normal levels to the point of robbing it from bone. So you can be technically deficient, but your serum levels are normal. I'm not sure how to communicate this effectively yet but I have no doubt the majority of the people on this community are deficient and it is leading to a host of problems.

 

[mf15]

Hi David:Yes kidneys are also not great,egfr around 60. But do not believe that has anything to do with the hi ph I found. Magnesium oxide is quite basic,which would raise urine ph. I try and stay on the high ph side anyway use bicarbonate, but over ph 8 is
probably too high.
Which magnesium salt are you using,citrate,chloride,gluconate,ascorbate,oxide.
Old Mike

 

[David]

I rotate oxide, glycinate, and glycinate/citrate.

kidneys are able to limit urinary excretion of magnesium when intake is low

Because of the potential risks of high doses of supplemental magnesium, especially in the presence of impaired kidney function, any disease treatment trial using magnesium doses higher than the UL should be conducted under medical supervision.

Source

 

[mf15]

Thanks David: Dont worry wont supplement over 350 mg/day. I have just gotten some
mgcl2 so will see how that works,I diluted it so 1ml gives me 60 mg magnesium, taste is real bad,ph is on the acid side.
Old Mike