Phthalate in sulfasalazine en. I'm concerned.

[Crohn2357]

Hello. I've started using sulfasalazine en tablets 3 days ago for my joint pain. It is helping my joints but it has phthalate (Cellulose acetate phthalate) in it. Phthalate is used to make the enteric coating of the tablets and it is a known endocrine disruptor, possibly carcinogen too.

The thing is, non enteric sulfasalazine isn't available in my country and I want to keep using this drug. I really don't want to use methotrexate again but I have concerns about this matter.


about phthalate:
www.naturalnews.com/034604_pills_phthalates_timed_release.html
www.prevention.com/health/healthy-living/dangers-pthalates-pill-coating
www.naturalnews.com/027514_phthalates_feminization.html
www.ncbi.nlm.nih.gov/pmc/articles/PMC1913587/
journals.plos.org/plosone/article?id=10.1371/journal.pone.0114003
http://www.rodalewellness.com/health/drugs-inactive-ingredients

Remember asacol was banned by FDA because of phthalate.

Presence of phthalates in gastrointestinal medications: Is
there a hidden danger? (talks about 5-asa too)
www.wjgnet.com/1007-9327/pdf/v19/i41/7042.pdf

Phthalates in 5-Aminosalicylates:
/www.healthplexus.net/files/content/2012/0207/0207phthalates.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649218/

the mean urinary concentration of monobutyl phthalate, the main DBP metabolite, among these mesalamine users was 50 times higher than the mean for nonusers

Do you have any suggestion, any idea?
Thanks in advance.

 

[Crohn2357]

In both cases, you're looking to avoid products where a word containing "phthalate" winds up on the label. Diethyl phthalate and dibutyl phthalates are most linked to health problems, while phthalate polymers like hypromellose phthalate, cellulose acetate phthalate, and polyvinyl acetate phthalate are believed to be more benign because the body doesn't readily absorb them. "However, sometimes these are combined with a phthalate plasticizer, such as diethyl phthalate, so you still need to get the most complete information about the product," says Kelley.”

http://www.rodalewellness.com/health/drugs-inactive-ingredients

So, at least sulfasalazine tablets have cellulose acetate phthalate. Asacol, for example has dibutyl phthalate.