Mine is very mild. My everyday activities aren't really affected, other then at the gym I can't go on the treadmill, I have to stick to swimming or the bike. But the knees also don't feel 100%, but I'm not sure if expecting the knees to feel completely normal is a realistic expectation. I wonder if this is as good as it's gonna get? My GI mentioned switching my Imuran to methotrexate at one point but then thought it might be better to stay on Imuran and maybe switch to remicade, since my body has no ba side effects from Imuran and tolerates it well.