Prometheus IBD SGI Serology

[zHunt]

That's what the order on my lab sheet said when I had this test done over the summer. It was drawn through a vein in my hand with a weird needle because they couldn't get my vein in my arm.

I'm wondering what the accuracy of this test is. I've heard earlier generations being incredibly inaccurate, with an improvement in the newest gen one. But still, have heard that the ClevelandClinic won't even consider this test.

How often are false negatives? I wonder how many people on this forum that do have IBD tested negative with this test.

 

[Clash]

I think if you goto the Prometheus website it gives you the accuracy and specificity. I think also if you Google the test in PubMed you will also come across some studies focused on this. I know it didn't get great result in one pediatric study but there are others. You can also read about it in this forum's wiki that is backed up by credible articles. Lastly, if you use the forum search bar and key words "Prometheus accuracy" then it will pull up threads discussing this topic.

 

[Farmwife]

My dd will be getting this done during her routine labs tomorrow.
Her GI said that it's not "full proof for accuracy" meaning their is false negatives but she said its just another piece of the puzzle.

 

[DustyKat]

This is but one piece of info on ASCA, this is what the test is called in Australia but I don’t know how it compares with Prometheus IBD SGI Serology.

ASCA is positive in approximately 60-70% of patients with Crohn’s disease,
10-15% of patients with ulcerative colitis and only 0-5% of healthy control subjects

So certainly room for movement in accuracy.

From our own perspective, my daughter was diagnosed 8 years ago and at that time the test wasn’t available here. Last August the GP ran the test after she became ill with what turned out to be a case of gastro. I don’t why he ordered as it is a bit like doing something after the horse has bolted. Anyway I was curious to see if her results matched up with what we know. She had early onset disease that took a severe course requiring surgery early in diagnosis due to perforation. This is another quote from that same source as above:

Amongst the Crohn’s disease patient population, those testing positive for ASCA appear to have a poorer prognosis than those testing negative. For example, ASCA-positive patients are more likely to develop complications (eg, internal fistulas, fibrostenosis, perianal disease) or require surgical intervention.

http://www.moavenandpartners.com/doctors/information_form/asca-testing-for-crohns-disease.shtml

She certainly does fit this description and her results were solidly positive.

I have recently been investigated for Crohn’s due to chronic upper abdominal pain. I didn’t agree with the GP but was happy to have scopes done. I don’t have Crohn’s and my ASCA returned a solidly negative result.

So for us the test was reflective of our respective conditions.

Dusty. xxx

 

[baistuff]

As of now, the only real use is to POSSIBLY help differentiate between CD and UC. It cannot rule out or officially rule in an IBD diagnosis. However in those with an indeterminate colitis, it may help to differentiate. It is not a diagnostic tool in and of itself. There is some data that in those with confirmed disease that its may predict severity, but that is not widely accepted at this point.