sibo, sifo, candida, biofilms

Crohn's Disease Forum

Help Support Crohn's Disease Forum:

C

cheka

Joined
Mar 31, 2024
Messages
219
sibo is another contributor to many of our autoimmune and leaky gut issues. antibiotics are the medical solution. there is another option - a kinder, gentler antibiotic that's suitable for every day use. the technology behind it is amazing.

diving into crohns with you guys is convincing me that sibo is a big player in crohns. if it were me, i would take a hard look at this stuff. there's a version on amazon called i26. it has a good batch of reviews to go through.

not my bold below

https://igynutrition.com/there-is-more-to-a-hyperimmune-egg-than-you-may-know/
 
Last edited by a moderator:
webmd reviews are a great resource - for drugs or supplements. here's the link to hyper immune egg webmd reviews. also had to copy and paste one that mentions crohns

https://reviews.webmd.com/vitamins-supplements/ingredientreview-1130-HYPERIMMUNE-EGG
I've used hyperimmune egg, I26, since 2001 for Crohn's disease. I take 2 servings a day. I've been in 'remission' beginning in the 3rd month after starting on it. My doctor was able to reverse my colostomy 5 months after starting using i26. I have almost no abdominal pain anymore, or diahrrea, and sleep through the night. I was at 112 lbs when starting on it, and I'm 5'10". Have been at 165-170 since 2003.
 
a common cause of sibo is low stomach acid. one function of the ultra low ph of the stomach is to kill pathogens, the most famous being h. pylori (the cause of ulcers).

low acid lets some bad guys slip by. they set up shop in the small intestine and start doing damage. this can/does lead to leaky gut - bad guys mess up the gut liner and the processes that maintain and repair it. a cause of crohns not unlikely...

how to top off your stomach acid -- a little bit of apple cider vinegar with meals or betaine hcl. i read that cayenne pepper supplement can help the stomach processes too - but not sure about trying it with crohns. we add a tablespoon or two of acv to our bone broth.

one big problem is carbonated beverages - eliminate them - or drink them away from meals on empty stomach. brother in law was a dr pepper-aholic. he paid the price -- hospitalized with ulcers (cause = h. pylori). he has since stopped drinking dr with meals. so far so good

people often mistakenly blame high stomach acid for heartburn/gerd. then they make things worse by taking things that reduce acid. they are setting themselves up for sibo/leaky gut/crohns/autoimmunes by doing that

takeaway = be sure to keep your stomach acid optimized
 
recent paper on sibo

low stomach acid and sibo. then sibo to leaky gut. then autoimmune disease. all started with low stomach acid - or more likely, eating/drinking things that neutralize the stomach acid

https://pubmed.ncbi.nlm.nih.gov/31536241/
Small intestinal bacterial overgrowth (SIBO) is the presence of excess colonic bacteria in the small intestine. These excess organisms result in multiple intestinal symptoms like abdominal pain, bloating, diarrhea, and rarely malabsorption. . The proximal small intestine typically contains relatively few bacteria due to the presence of stomach acid and the effects of peristalsis.

When the protective mechanisms (peristalsis, stomach acid) against excessive bacterial growth fail, small intestinal bacterial overgrowth (SIBO) can manifest.
 
heard a recommendation for sibo from an expert i highly respect. it's a seaweed extract call fucoidan. available as a supplement -

fucoidan also tripped my wire a few months ago - i was helping a lady with her cancer and found that it has anti-cancer studies/papers on pubmed. some with promising conclusions. i sent her the links and she's been on it for a couple of months with no side effects.
 
interesting - they took bugs from ibd/crohns guts and put them in mice

https://pubmed.ncbi.nlm.nih.gov/38532703/
Our study provides the first evidence that the transfer of a dysbiotic community from CD patients can lead to spontaneous inflammatory changes in the colon of xGF mice and identifies a signature microbial community capable of promoting colonization of pathogenic and conditionally pathogenic bacteria.
 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917804/
2023 Feb

Impact of Small Intestinal Bacterial Overgrowth in Patients with Inflammatory Bowel Disease and Other Gastrointestinal Disorders—A Retrospective Analysis in a Tertiary Single Center and Review of the Literature


5. Conclusions
In our study, we could clearly show that SIBO plays a role in IBD patients and other gastrointestinal disorders. Its prevalence in patients with IBD in remission might still be underestimated. Especially in patients with CD, SIBO is increasingly found in older age. Clinically, SIBO should be routinely considered in order to optimize the treatment of IBD patients.
 
Last edited:
Written By:
Dr. Claire Lockridge ND, has a degree in Naturopathic Medicine from the Canadian College of Naturopathic Medicine and a Bachelor of Science undergraduate degree with a minor in Nutrition from the University of Arizona. She integrates her extensive knowledge of nutrition and psychology to provide optimal care to her patient base.


https://citynaturopathic.ca/sibo-natural-treatment/
 
Last edited by a moderator:
moringa, a popular supplement for a variety of benefits

https://jppres.com/jppres/moringa-oleifera-fungistatic-effects-on-candida-albicans/
Fungistatic effect of Moringa oleifera Lam. on the metabolism changes of Candida albicans

Conclusions: The extract of M. oleifera has increased metabolism changes (stress response) of C. albicans cells, which correlate with the ability to inhibit growth and biofilm formation for 24, 48, and 72 h.
 
informative study, just posted a clip of it. the first signs of relapse include the loss of the main scfa/butyrate producers. later in the relapse process the minor scfa/butyrate producers can go down too, worsening symptoms.

in the conclusion the researchers speculate that a probiotic cocktail combined with anti-TNFα could reconstitute a healthy microbiome. specifically they cited the probiotic cocktail that i'm posting below this post.

https://www.nature.com/articles/s41598-022-23757-x
Gut microbiota analysis for prediction of clinical relapse in Crohn’s disease

Investigating further this microbiota/severity association revealed that the first signs of aggravation are (1) a loss of the main anti-inflammatory Short-Chain Fatty Acids (SCFAs) Roseburia, Eubacterium, Subdoligranumum, Ruminococcus (P < 0.05), (2) an increase in pro-inflammatory pathogens Proteus, Finegoldia (P < 0.05) while (3) an increase of other minor SCFA producers such as Ezakiella, Anaerococcus, Megasphaera, Anaeroglobus, Fenollaria (P < 0.05). Further aggravation of clinical signs is significantly linked to the subsequent loss of these minor SCFAs species and to an increase in other proinflammatory Proteobacteria such as Klebsiella, Pseudomonas, Salmonella, Acinetobacter, Hafnia and proinflammatory Firmicutes such as Staphylococcus, Enterococcus, Streptococcus. (P < 0.05).

To our knowledge, this is the first study (1) specifically identifying subgroups of microbiota profiles in CD patients, (2) relating these groups to the evolution of symptoms over time and (3) showing a two-step process in CD symptoms’ worsening. This paves the way towards a better understanding of patient-to-patient heterogeneity, as well as providing early warning signals of future aggravation of the symptoms and eventually adapting empirically treatments.
 
Last edited:
this post links to the one above --- researchers suggested this cocktail to be used with the anti-tnf

https://www.nature.com/articles/s41598-017-11734-8
Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity

This study provides proof-of-concept data for the therapeutic potential of butyrate-producing bacteria in CD and supports the future preclinical development of a probiotic product containing butyrate-producing species.
 
good read on dissolving biofilms

https://www.clinicaleducation.org/r...lms-with-fibrinolytic-enzymes-autism-support/
Dissolve Biofilms With Fibrinolytic Enzymes

treating chronic bacterial infections and biofilms that involves some new insights and relies in part on fibrinolytic enzymes like nattokinase and lumbrokinase
Focus: What exactly is your therapy and what sequence do you use?
Click to expand...
Cohen: I start with enzymes like nattokinase and lumbrokinase, as well as other mucolytic enzymes, to get the best, broad fibrinolytic effect. Dr. Usman feels nattokinase is particularly good at degrading strep biofilms and I think that strep is a very big player in these childrens’ health

Remember, these patients are very young; some are just a few years old. So I will recommend half a capsule of each, two times a day. That would be a 50 milligram capsule of nattokinase, and a 20 milligram capsule of lumbrokinase. First do the enzymes along with EDTA, then thirty minutes later, add in an arsenal of antimicrobials. I use formulations containing berberine, artemisinin, citrus seed extract, black walnut hulls, artemisia herb, echinacea, goldenseal, gentian, tea tree oil, fumitory, gentian, galbanum oil, oregano oil, neem, and pharmaceuticals as well when necessary, such as Vancomycin, Diflucan, Gentamycin. I use a different one every day. Then an hour later you come in with the binders to help mop up the debris. I use chitosan, citrus pectin, a special bicarbonate formula, organic germanium, chlorella and others. I also use buffering agents, such as buffered vitamin C, since when the body is destroying bacteria it becomes acidic. Minerals must be assessed, and repleted when necessary. I test bloodwork and “pees and poos” (urine and stool) every two months to monitor the process.
 
https://www.sciencedirect.com/science/article/abs/pii/S0003996919300044
Effect of Polyphenol-Rich Cranberry Extracts on Cariogenic Biofilm Properties and Microbial Composition of Polymicrobial Biofilms
Cranberry-treated biofilms showed significant drops in biomass (38% reduction, P <  0.001), acidogenicity (44% reduction, P <  0.001), EPS/microbial biovolume ratios (P =  0.033), and CFU counts (51% reduction, P =  0.001). Furthermore, the cranberry extracts effected a significantly lower relative abundance of caries-associated Streptococcus sobrinus (fold change 0.004, P =  0.002) and Provotella denticola (0.002, P <  0.001), and a significantly higher relative abundance of the health-associated Streptococcus sanguinis (fold change 90.715, P =  0.001). The cranberry extract lowered biofilm biomass, acidogenicity, EPS/microbial biovolumes, CFU counts, and modulated a beneficial microbial ecological change in saliva-derived polymicrobial biofilms.
Click to expand...
 
butyrate again, this time for biofilms

https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1151552/full
In addition, we propose that the abrupt decline in probiotics, particularly those that produce butyrate, modifies the pattern of bacterial growth from dispersed to aggregated, which encourages the creation of biofilms. In vitro experiments showed that short-chain fatty acids (SCFAs) inhibit the formation of biofilms in species including E.coli (Amrutha et al., 2017), Salmonella typhimurium (Lamas et al., 2019), Staphylococcus epidermidis (Nakamura et al., 2020), and Streptococcus gordonii (Park et al., 2021). However, as IBD progress, active producers of SCFAs in health such as Firmicutes suffer great reduction.

Moreover, it has been demonstrated that antibiotic treatment lowered SCFAs in the GI tract, which speeded up biofilm growth, morphogenesis, and GI colonization of Candida albicans (Guinan et al., 2019). Therefore, SCFAs are plausible natural inhibitors of biofilm formation which contribute to explaining the dual influence of antibiotics treatment on IBD patients.
 

Similar threads

joelsprechman
I feel better than ever! Healing, naturally, and holistically. Off medication, refused surgery.
Replies
16
Views
13K
SaxLady
SaxLady
Igor_Passau
Immune system molecule weaves cobweb-like nanonets to snag Salmonella, other intestin
Replies
1
Views
2K
kiny
kiny
S
An Alternative View of Crohn's Disease and IBD
Replies
8
Views
2K
scottchopchop
S

Latest posts

Back
Top