I am sorry to hear about your brother. You are a good sister trying to find answers for him. His hair loss could also be from mal nutrition - deficiency in important minerals due to poor absorption. Also, before you rule out Remicade, you have to find out more details - his levels - dosage - the questions that were mentioned in earlier posts. There are other conditions that can result from having Crohn's, and one of them is uveitis (inflammation of the eyes). So from what I understand, your brother's current doctor will be doing a blood test to check levels of Remicade, so that's a good place to start. Remicade has worked great for my son. I do hope that you get answers for your brother. After the levels come back, the doctor can determine if a change is necessary.