About 2.5 hours. 2 actually running the Remi then .5 hour putting in iv, mixing meds, them taking out IV. Some places make you wait an hour or so after your Infusion to watch for reaction. I did that for my first three infusions. Risks and side effects are very similar though Remi has an increased risk of allergic reaction and anaphylaxis as it is not entirely human. It is not very common however and the nurse is fully equipped to handle anything should there be an issue.