Think This Might Be UC

[hawaiian988250]

Hi, all. I have been going to a GI for years now and just recently got some new tests done and am confused by the results. Hoping you can help!


I had the Prometheus test done and it indicates UC. It also says My AutoAntibody ELISA is 34.2 EU/ml and the normal range is <19.8 EU/ml. What does this mean/indicate? My IFA Perinuclear Pattern was NOT DETECTED and the DNAse Sensitivity was NOT DETECTED.


My STAT 3, NKX2-3, ECM1, and ATG16L1 all show variant DETECTED. THe reference genotype says Variant not detected for three of them but Variant DETECTED for STAT 3. MY ICAM 1 came back at 0.43 ug/ml, VCAM-1 at 0.47 ug/ml.My hematocrit and hemoglobin were both HIGH and my C-reactive protein was <0.5 MG/DL.


My colonoscopy indicated I had some abnormalities such as rare crypt abscesses, cryptitis, scalloped folds/edges.

Im confused and hoping someone can help!

 

[kiny]

If you want to know what the terms mean, I can help. CRP is measured in blood, it's used to see if there is inflammation. Immune cells release cytokine, they're signaling cells, and they stimulate the liver, and the liver releases CRP in response. You can compare them to antibodies, but unlike antibodies, they have broad specificity, the only thing you can measure is if there is an immune response and inflammation happening in the body.

Crypt abscesses and scalloped folds, are what they say they are. The doctor took a biopsy during your colonoscopy, and a histology test done under a microscope showed crypt abnormalities, meaning you probably have some inflammation there.

Hematocrit and hemoglobin. Hgb and Hct testing, is done to see if you're anemic, or if you lost a lot of blood.

The gene testing. Some of those genes they tested are related to crohn's. ATG16L1 for example, ATG stands for autophagy, autophagy is involved during cell degradation, but recently has been implicated in crohn's disease, as a pathway for killing intracellular pathogens. Anomalies in ATG16L1 sometimes indicate crohn's, but it's very non-specific.

Prometheus Testing, I have no idea, it's a brand test, it doesn't exist where I live. All those antibody tests like ASCA tests rarely tell you anything. You can have antibodies years after infections, it's rarely useful, but it's how companies make money.


As far as saying if anything indicates UC or Crohn's, diagnosing is your doctor's job, no one but your doctor can do that. Hope this helps.

 

[hawaiian988250]

Thanks. I guess we'll see what the doctor says when I go.