Thoughts on the Disease

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Oct 7, 2014
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Hello There,

I recently became involved with a woman (a few dates) that had undergone antibiotic's for a sinus infection and out of which had developed an autoimmune disease / Crohn's / Ulcerative Coilitis, i believe they are giving her a methotrexate infusion every 6 weeks or so to wipe out her white blood cells which are attacking her digestive tract.

I did a bit of research over the past few days and just wanted to run my thoughts past you all.

It seems that the methotrexate infusion (chemo therapy?) is simply fighting the symptoms rather than the cause, the white blood cells. But not what is causing them to run rampant.

It seems to me that since this all started after a course of antibiotics that this could be bacteria related, is it possible that the white blood cells could be onto something undetected and not necessarily acting crazy?

The way i picture it in my head is after taking antibiotics there is a bacteria tug of war match that starts between good and bad bacteria, is it possible that the bad bacteria won here and it wasnt detected? Then the bad bacteria goes on to inflame or cause issue with healthy tissue, at which point the white blood cells start to attack it?

If so can you detect or measure bacteria growth? What causes good bacteria to be there in the first place? Is there something that can disrupt this "source" of good bacteria or can it be improved upon?

Can you specifically target bad bacteria with a specialized anti-biotic? Rather than one that fights all bacteria?

Could it be possible to try varying forms of anti-biotics until you find the one that kills off the rampant bad bacteria then assist the good bacteria in the tug-of-war match afterwards with a pro-biotic of some sort?

I'm an IT guy and naturally curious, i spend most of my time diagnosing technical (not medical) issues during the day.
 
It's highly unlikely that one dose of anti-biotics for a sinus infection would give her crohns it may have been bubbling away in the background for a few years it is a common thread on here that another illness may tip a crohnie over the edge I.e Make it more obvious in my case I got shingles,badly burned at work and averaged 80/90 hours a week for 4months not bright of me so after that I definitely wasn't,t at my best,but after diagnosis and thought things had been going wrong for a while.there is no cure just now for crohns just a lot of stuff to bring it under control and hopefully get back to normal.
 
There have been many experiments with antibiotics over the years and some people do seem to respond to the multiple antibiotic approach but not many.

The most promising antibiotic approach right now is the trials using multiple antibiotics to try to eliminate MAP. Whether this ultimately will stop crohns is unknown yet.

Link on discussion of MAP vaccine http://www.crohnsforum.com/showthread.php?t=59071
 
Josh,
Good thoughts, good questions. Read up on MAP and treatment for it, it is along the same line of thinking. One of the problems with Crohn's, and there are many problems, is that what works for one person may not work for another.
 
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