I'm on 200 mg/day (male 165 lbs). I've been on it for about 6 years, not always this high of a dose, but pretty close.
I used to take the full dose before bed every night. My GI claims it doesn't matter as its effectiveness is about building up long term concentrations in the body - not about an immediate response to the latest dose.
About a year ago I switched to taking half right before bed, half in the morning with breakfast. That seems to have helped with the fatigue a bit, but that's anecdotal - my overall condition might have improved with the increase in dosage that prompted me to make the change.
Good luck!