Highlights
• After NMN feeding, the improved morphology of inflamed intestines, restored length of colon and enhanced mucosal permeability were discovered.
• The expression of pro-inflammatory factors in serum was also decreased after NMN administration.
• Significant alterations in the composition and abundance of intestinal flora in IBD mice were found.
• This study provides some evidences for the application of NMN in the prevention and treatment of IBD, which is important for clinical application.
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• After NMN feeding, the improved morphology of inflamed intestines, restored length of colon and enhanced mucosal permeability were discovered.
• The expression of pro-inflammatory factors in serum was also decreased after NMN administration.
• Significant alterations in the composition and abundance of intestinal flora in IBD mice were found.
• This study provides some evidences for the application of NMN in the prevention and treatment of IBD, which is important for clinical application.
Treatment of inflammatory bowel disease: Potential effect of NMN on intestinal barrier and gut microbiota
Nicotinamide mononucleotide (NMN) exerts physiological effects in mammals through its conversion to nicotinamide adenine dinucleotide (NAD+). In this …
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