What could this mean - "big things coming up for Crohn's"?

[Optimistic]

Does this ring a bell with anyone? I'm posting here because this seems to be the brain trust. .

I was in a large group recently and side conversation was about someone's child using an NG tube (not an IBD issue). I mentioned that my son had used one with Crohn's. A woman (not from my immediate group but associated loosely with someone I work with) chimed in enthusiastically, "can he hang on for another year or so? There are big things coming up." Everyone shifted and I didn't get a chance to continue conversation with her.

I'm going to be tracking her down this week through the mutual connection. All I know from afar is she is a senior medical researcher who has worked for a few different US and European pharma companies. Not Nestle so she I'm assuming/hoping she wasn't talking about their new venture on MAPS or whatever that was.

Any ideas?

 

[my little penguin]

There are always "big things coming up" for crohns
Unfortunately
I forgot the paper but it had a bullseye chart of everything in the pipeline and all the different phase they were at
Ridiculous number of things
But most don't cut the mustard
And then even when they make it to adult crohns
It still takes even longer for kiddie crohns
So I don't get too excited after 5 years

 

[Optimistic]

MLP - well that stinks to have gone through all those hopes and watch them fail. Ugh.

This woman was standing in midst of other head of research for Pharma companies types and I'm going to hope that bc no one said she was an idiot ha then maybe she had some belief that something was going in right direction with something? Although the GIs we've seen at Boston and Cincinnati said don't hold your breath two years ago.

 

[Scared1]

Hi Optimistic,
Don't lose your optimistism - because with thenresearch they are doing now on trying to find the cause, this is different then the methods of research before which was focused on symptom treatment. I have researched info posted from 2002 and the types of news and treatments cominf out, very different from now where the shift is cause rather than system management. So based on my many hours of researching, I truelt believe in a few uears - which to me mean less than 8-9 years, big things are truely coming. I am not surprises you are not hearing anything from you GI - their role and rightfully so is to provide medical care as the standard currently is, and new treatments and methods won't be provides or talked about I think for numerous reasons because people want to get all the info and approvals before they do so. So don't be sad, I truely your precious kiddo will find relief in their lifetime with much more of his life to enjoy

 

[my little penguin]

Biological agents for inflammatory bowel diseases (IBD) targeting tumor necrosis factor (TNF) have changed the way to treat IBD refractory to standard medications and allowed us to reach new therapeutic goals such as mucosal healing and deep remission. A better understanding of the components of the pathological processes that are a hallmark of IBD has led to the development of a new family of biological agents in Crohn’s disease and ulcerative colitis. Biosimilars, which are copy versions of currently licensed biological agents, will be soon available. The biosimilar of infliximab is as effective and as safe as its originator in rheumatologic conditions, while a new anti-TNF agent, namely golimumab, has been recently approved for refractory ulcerative colitis. Beyond TNF blockers, anti-adhesion molecules appear to be a potent drug class for IBD. Vedolizumab was recently approved for both Crohn’s disease and ulcerative colitis. Numerous other compounds are in the pipeline. Ustekinumab looks very promising for Crohn’s disease. Smad7 antisense oligonucleotide might enrich our armamentarium if preliminary data are confirmed in upcoming clinical trials. Herein, we review the efficacy and safety of new and emerging biological agents that are currently investigated in IBD clinical trials.

From
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314302/

 

[my little penguin]

http://online.ccfa.org/site/DocServ...ides_New-Drugs-and-Treatments.pdf?docID=17225

Presebtation

 

[my little penguin]

http://www.practicalgastro.com/pdf/...-Inflammatory-Bowel-Disease-Drug-Pipeline.pdf


More on drugs in the pipeline

Enjoy

 

[Maya142]

I think Stelara was filed for approval at the end of 2015 and should be approved this year. That would be one more option and a totally different kind of drug (IL 12 and 23 inhibitor).

 

[Scared1]

Some non-drug related research:
1. AIEC - using SSI's as a treatment options: http://www.qubiologics.com/free-seminar-microbial-involvement-in-crohns-disease-2/
2. How microbiome changes may cause IBD within the context of fecal transplants: http://www.cmghjournal.org/article/S...040-6/fulltext
3. Clinical Trials for AMAT therapy by Redhill being conducted now as is the new vaccine for MAP begins human trials this year.

These are just some...there are quite a few threads that discuss these. This is of course NOT saying that research into biologics and other drugs intended to deal with symptoms is not going to continue (Mongerson is actually very promising) but there are more research being done on causes of the disease as well, as compared to before. This is directly due to the advancement of technologies that didn't exist even 20 or 10 years ago.

 

[Scared1]

http://www.practicalgastro.com/pdf/...-Inflammatory-Bowel-Disease-Drug-Pipeline.pdf


More on drugs in the pipeline

Enjoy

This is great, thanks!