Which prebiotics do you use?

[kiny]

Which prebiotics do you use?

 

[nogutsnoglory]

There is FOS in the Renew Life probiotic I take but I'd prefer there wouldn't be. Prebiotics are sugars that feed all bacteria. So we may be helping the bad gut guys in there with them too.

 

[kiny]

yes, using it at the same time is best to limit fermentation by other bacteria, prebiotic make probiotic magnitudes more potent

In a small, open-labeled trial of 10 active CD patients, 21 d of
15 g oligofructose and inulin (Synergy) oral intake resulted in a
significant decrease of disease activity from baseline, an increase
of intestinal bifidobacteria, and concurrent modifications of the
innate immune system, such as increased expression of Toll-like
receptors and increased IL-10 expression in mucosal dendritic
cells (39) (Table 2).
The link between the intestinal microflora as part of the hostbacteria
interaction for the pathogenesis of IBD is currently being
heavily studied. Altering the composition of the microflora using
probiotics and/or prebiotics holds promise as a therapeutic
strategy for ameliorating chronic intestinal inflammation. Future
developments in this field must include rigorous double-blind,
placebo-controlled trials, using probiotics and/or prebiotics,
along with a further understanding of their protective mechanisms.
Because of their excellent safety profile and lack of serious
side effects, there is little contraindication to the consumption of
prebiotics, probiotics, and their combination (synbiotics) by IBD
patients. Further understanding of the interactions between
microbes and the gastrointestinal tract will help identify which
strains of bacteria and/or which prebiotics may be effective in
different types of chronic inflammatory disease.

 

[nogutsnoglory]

So you are saying the probiotics eat that before the bad bacteria get it?

 

[kiny]

yes, it's for the benefit of the fermentation, not really to make them grow more (well it is nice side effect too), because otherwise you could just swallow more bacteria or use the prebiotic in vitro and wait until they grew, the fermentation increases butyrate and IL-10 and lowers inflammation

there is a bacteria called Faecalibacterium prausnitzii, for some reason it disappears in many people with crohn who have it before disease, because inflammation also alters gut flora composition, but F prausnitzii makes a lot of butyrate and using inulin or oligofructose and letting commensal bacteria ferment it increases what was lost, in many studies of prebiotic they don't even use probiotic, the good thing doesn't just come from the bacteria, but what they ferment and release when they do that, butyric acid

you can just buy butyric acid but it doesn't have the same effect, because you would need to eat way too much because most never arrives at the spot where someone has crohn's disease, but commensal bacteria are already in the right spot, you just need to give them something that will get to them unharmed to ferment, like inulin or oligofructose or whatver carb that works, and they will do the work for you and produce butyric acid for you (they have other benefits like IL-10 increase and some other)

someone should make a Faecalibacterium prausnitzii probiotic

 

[nogutsnoglory]

yes, it's for the benefit of the fermentation, not really to make them grow more (well it is nice side effect too), because otherwise you could just swallow more bacteria or use the prebiotic in vitro and wait until they grew, the fermentation increases butyrate and IL-10 and lowers inflammation

there is a bacteria called Faecalibacterium prausnitzii, for some reason it disappears in many people with crohn who have it before disease, because inflammation also alters gut flora composition, but F prausnitzii makes a lot of butyrate and using inulin or oligofructose and letting commensal bacteria ferment it increases what was lost, in many studies of prebiotic they don't even use probiotic, the good thing doesn't just come from the bacteria, but what they ferment and release when they do that, butyric acid

you can just buy butyric acid but it doesn't have the same effect, because you would need to eat way too much because most never arrives at the spot where someone has crohn's disease, but commensal bacteria are already in the right spot, you just need to give them something that will get to them unharmed to ferment, like inulin or oligofructose or whatver carb that works, and they will do the work for you and produce butyric acid for you (they have other benefits like IL-10 increase and some other)

someone should make a Faecalibacterium prausnitzii probiotic

I started a thread on that bacteria strain about 4-5 months ago. I forget exactly why but scientists think its hard to patent and don't expect it will come to market.

 

[kiny]

I started a thread on that bacteria strain about 4-5 months ago. I forget exactly why but scientists think its hard to patent and don't expect it will come to market.

kickstarter project to make Faecalibacterium prausnitzii probiotic, I will back

 

[Crohn2357]

I'm wondering that, when we take probiotics with prebiotics orally, they fall down to the stomach and some of the probiotics die in the stomach acid, then prebiotics and the rest of the probiotics go to intestine. Before the rest of the probiotic bacterias locate and colonize in the intestine, harmful bacterias which already colonized and located in the intestine can feed with the prebiotics and increase.
Is that wrong? What is your ideas?